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Tumor angiogenesis and invasive capacity is influenced, in part, by events in the tumor microenvironment. Vasquez Rodriguez et al. investigated how cytokines and growth factors released by breast adipocytes modify the tumor microenvironment leading to increased angiogenesis and metastasis. They found that release of VEGF and IL-8 by breast adipocytes causes increased tumor angiogenesis. Additionally, elevated IL-8 in the tumor microenvironment resulted in the recruitment of neutrophils and modified expression of cell adhesion molecules on both neutrophils and cancer cells ultimately leading to increased dissemination of tumor cells.

Study the tumor microenvironment with our new LEGENDplex™ Human Angiogenesis Panel allowing you to simultaneously quantify 10 key targets involved in the complex process of angiogenesis!
Adapted from Vasquez Rodriguez et al. 2018. Front. Immunol. Article.
Targets analyzed by the kit:
Angiopoietin-1 IL-6
Angiopoietin-2 PECAM-1
CXCL8 (IL-8) PlGF
EGF TNF-α
FGF-Basic VEGF
Panels:
Angiogenesis Panel 1 with Filter Plate 740697
Angiogenesis Panel 1 with V-Bottom Plate 740698
Other Related Products
CCL2 LFA-1
CCL5 MUC-1
CXCL8 (IL-8) VCAM-1
DAPI VEGF
ICAM-1  
Need help using LEGENDplex™ Software v8 to analyze your data? We've released a series of video tutorials to walk you through every step of data analysis from uploading your files to generating reports. We've also updated our Software User's Manual so you can follow along with the videos. Watch the videos and download the manual today!
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