Epigenetics and Disease States
Beyond the code laid out by your DNA sequences and genetics, there is another layer of control that can dictate which genes are activated or silenced. Epigenetics are heritable, reversible forms of gene modification that function independently of the DNA sequence. Common examples include DNA methylation, histone methylation, acetylation, phosphorylation and ubiquitination. Epigenetic modifications are being studied in several disease models as detailed by Heerboth et al. below. BioLegend provides a diverse set of products for the detection of both histones and their epigenetic modifications.
Adapted from: Heerboth, S. et al. 2014. Genetics and Epigenetics. 6:9. Pubmed
Chromatin can be found in the heterochromatin (condensed) form. Histone acetyl transferases (HATs) place acetyl groups on histones, causing them to de-condense into the euchromatin state, allowing for the transcription of their genes. This process can be reversed with histone deacetylases (HDACs). These processes have been implicated in several areas, including cancer, metabolism, and neurological disorders. In cancer cells, DNMT1, an enzyme that methylates CpG regions, is often found to be highly upregulated. This hypermethylation recruits HDACs and can silence tumor suppressing genes, promoting tumor development. CpG methylation is also tightly regulated in neuron development. Mutations, duplications, or insertion of the methyl CpG binding protein 2 (MeCP2) gene has been found to lead to Rett syndrome, a rare postnatal neurological disorder that occurs primarily in females.
Related Products
Human, Mouse, and Rat Antibodies
DescriptionCloneReactivity
GCN5Poly6072Human
H2A.XPoly6133Human
H2A.X Phospho (Ser139)2F3Human, Mouse
HDAC110E2/HDAC1Human, Mouse
HDAC1Poly6074Human, Mouse
HDAC23F3/HDAC2Human, Mouse, Rat
HDAC33G6Human, Mouse
HDAC414A9C47Human
HDAC4Poly6077Human, Mouse
HDAC618E2SCHuman
Histone H3Poly6019Human, Mouse
Histone H3 (C-terminus)1B1-B2Human, Mouse, Rat
Histone H3 Dimethyl (Lys9)5E5-G5Human, Rat
Histone H3 Monomethyl (Lys9)7E7.H12Human, Mouse
Histone H3 Nonmethyl (Lys9)9B1-2G6Human
Histone H3 Phospho (Ser10)11D8Human
Histone H3 Phospho (Ser28)HTA28Human
Histone H3 Trimethyl (Lys9)6F12-H4Human, Rat
Histone H4 Monomethyl (Lys20)5E10-D8Human, Mouse, Rat
Histone H4 Trimethyl (Lys 20)6F8-D9Human, Mouse, Rat
HMGB13E8Human, Mouse, Rat
MECP2N227/21Human, Mouse, Rat
Recombinant Proteins
Description
Recombinant Human HMGB1 (carrier-free)
*Any references to promotions on this page may not be valid at this time. View our promotions page for the most up-to-date promotions.
Login/Register
Forgot your password? Reset Password
Request an Account