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Purified anti-MOG Antibody

Pricing & Availability
Clone
Poly28599 (See other available formats)
Regulatory Status
RUO
Other Names
MOG, Myelin Oligodendrocyte Glycoprotein
Isotype
Rabbit Polyclonal IgG
Ave. Rating
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Product Citations
publications
Poly28599_Purified_MOG_Antibody_1_051619.png
Western blot of purified anti-MOG antibody (Poly28599). Lane 1: Molecular weight marker; Lane 2: 10 µg of human brain lysate. The blot was incubated with 0.2 µg/mL of the primary antibody overnight at 4°C, followed by incubation with HRP-labeled donkey anti-rabbit IgG (Cat. No. 406401). Enhanced chemiluminescence was used as the detection system.
  • Poly28599_Purified_MOG_Antibody_1_051619.png
    Western blot of purified anti-MOG antibody (Poly28599). Lane 1: Molecular weight marker; Lane 2: 10 µg of human brain lysate. The blot was incubated with 0.2 µg/mL of the primary antibody overnight at 4°C, followed by incubation with HRP-labeled donkey anti-rabbit IgG (Cat. No. 406401). Enhanced chemiluminescence was used as the detection system.
  • Poly28599_Purified_MOG_Antibody_2_051619.png
    IHC staining of purified anti-MOG antibody (Poly28599) on formalin-fixed paraffin-embedded human brain tissue. Following antigen retrieval using Sodium Citrate H.I.E.R., the tissue was incubated with 1 µg/ml of the primary antibody overnight at 4°C. BioLegend's Ultra Streptavidin (USA) HRP Detection Kit (Multi-Species, DAB, Cat. No. 929901) was used for detection followed by hematoxylin counterstaining, according to the protocol provided. The image was captured with a 40X objective. Scale Bar: 50 µm
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859901 25 µg £86
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Description

Myelin Oligodendrocyte Glycoprotein (MOG) is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. It is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication, and mediate homophilic cell-cell adhesion. Diseases associated with MOG include Narcolepsy 7 and Rubella. Among its related pathways are Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. MOG may also act as a receptor for rubella virus during microbial infection.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Polyclonal
Host Species
Rabbit
Immunogen
Recombinant MOG expressed in E.coli.
Formulation
0.01 M PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C
Application

WB - Quality tested
IHC-P - Verified
Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.1 - 0.5 µg per mL. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 1.0 - 10 µg/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2810735 (BioLegend Cat. No. 859901)

Antigen Details

Structure
MOG is a 247 amino acid protein with an apparent molecular mass of ~28 kD.
Distribution

Tissue Distribution: Brain and spinal cord
Cellular Distribution: Plasma membrane

Function
MOG is involved in completion and maintenance of the myelin sheath and cell-cell communication.
Interaction
Myelin, Rubella virus
Cell Type
Neurons, Oligodendrocytes
Biology Area
Cell Adhesion, Immunology, Neurodegeneration, Neuroscience, Stem Cells
Molecular Family
Adhesion Molecules, Innate Immune Signaling
Antigen References
  1. Reindl M, et al. 2017. Curr Opin Neurol. 30(3):295.
  2. Hennes EM, et al. 2018. Neuropediatrics. 49(1):3.
Gene ID
4340 View all products for this Gene ID 17441 View all products for this Gene ID 24558 View all products for this Gene ID
UniProt
View information about MOG on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 05/16/2019

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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