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APC anti-human TSPAN33 (BAAM) Antibody

Pricing & Availability
Clone
SA17RN1 (See other available formats)
Regulatory Status
RUO
Other Names
Tetraspanin-33, BAAM, Penumbra, PEN
Isotype
Mouse IgG2b, κ
Ave. Rating
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Product Citations
publications
SA17RN1_APC_TSPAN33_APC_Antibody_040819.png
Human peripheral blood lymphocytes were stimulated overnight with recombinant human CD40L (TNFSF5) plus IL-4 and were stained with CD19 FITC and TSPAN33 (BAAM) (clone SA17RN1) APC (left) or Mouse IgG2b, κ APC isotype control (right).
  • SA17RN1_APC_TSPAN33_APC_Antibody_040819.png
    Human peripheral blood lymphocytes were stimulated overnight with recombinant human CD40L (TNFSF5) plus IL-4 and were stained with CD19 FITC and TSPAN33 (BAAM) (clone SA17RN1) APC (left) or Mouse IgG2b, κ APC isotype control (right).
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395405 25 tests £122
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395406 100 tests £243
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Description

TSPAN33, also known as BAAM, is a 32 kDa protein member of the TM4 superfamily (TM4SF). TSPAN33 have four transmembrane regions and two extracellular loops, one of them is a cysteine-rich long extracellular loop (LEL), characteristic of the TM4SF. TSPAN33 interacts with different molecules such as integrins and other tetraspanins. TSPAN33 is expressed by activated B cells, some B cell lymphomas, macrophages and in cells from the convoluted tubules and collecting ducts in the kidney. In macrophages TSPAN33 modulates TLR-induced proinflammatory gene expression, but its function in other cells is unknown.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Human TSPAN33-transfected cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Red Laser (633 nm)
RRID
AB_2801043 (BioLegend Cat. No. 395405)
AB_2801044 (BioLegend Cat. No. 395406)

Antigen Details

Structure
Member of the TM4 superfamily, TspanC8 subgroup, 32kD, 4 transmembrane regions, 1 cysteine-rich long extracellular loop (LEL).
Distribution

Activated B cells, some B cell lymphomas, macrophages, convoluted tubules and collecting ducts from kidney

Function
Modulates TLR-induced proinflammatory gene expression
Cell Type
B cells, Macrophages
Biology Area
Cancer Biomarkers, Immuno-Oncology, Signal Transduction
Molecular Family
Adhesion Molecules
Antigen References
  1. Pérez-Martínez CA, et al. 2017. Scand J Immunol. 86:23.
  2. Ruiz-García A, et al. 2016. J Immunol. 197:3371.
  3. Luu VP, et al. 2013. Clin Immunol. 149:388.
  4. Chen Z, et al. 2005. Cancer Genet Cytogenet. 162:95.
  5. Maecker HT et al. 1997. FASEB J. 11:428.
Gene ID
340348 View all products for this Gene ID
UniProt
View information about TSPAN33 on UniProt.org
Go To Top Version: 1    Revision Date: 04/08/2019

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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