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PE anti-human CD213a2 (IL13Rα2) Antibody

Pricing & Availability
Clone
47 (See other available formats)
Regulatory Status
RUO
Other Names
IL13BP, CT19
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
47_PE_CD213a2_Antibody_FC_100713
Human melanoma cell line A375 was stained with CD213a2 (clone 47) PE (filled histogram) or mouse IgG1, κ PE isotype control (open histogram).
  • 47_PE_CD213a2_Antibody_FC_100713
    Human melanoma cell line A375 was stained with CD213a2 (clone 47) PE (filled histogram) or mouse IgG1, κ PE isotype control (open histogram).
See PE spectral data
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360305 25 tests $153
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360306 100 tests $360
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Description

CD213a2, also known as IL13Rα2, is a type I transmembrane protein and member of the hematopoietin family. IL13Rα2 is the high affinity receptor for IL-13, but it possibly acts as a decoy receptor to antagonize IL-13Rα1/IL-4Ra-mediated IL-13 biological functions. IL13Rα2 is expressed by fibroblasts, smooth muscle cells, keratinocytes, and activated B cells. However, its presence on the cell surface is highly regulated. CD213a2 is also expressed in various types of cancer which makes it an attractive therapeutic target.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Recombinant human IL-13R alpha 2 Fc chimera
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Additional reported applications (for relevant formats) include:  Western blotting1, ELISA1, immunohistochemistry staining of frozen tissue sections1, and blocking (competes with IL-13 for binding).

Application References

(PubMed link indicates BioLegend citation)
  1. Balyasnikova IV, et al. 2012. J. Biol. Chem. 287:30215. (WB, ELISA, IHC, Block)
Product Citations
  1. Wen Y, et al. 2020. J Invest Dermatol. . PubMed
RRID
AB_2562620 (BioLegend Cat. No. 360305)
AB_2562621 (BioLegend Cat. No. 360306)

Antigen Details

Structure
Member of the hematopoietin family, type I transmembrane protein, contains 1 fibronectin type III domain
Distribution

Activated B cells, fibroblasts, smooth muscle cells, keratinocytes

Function
Possible decoy receptor, antagonist of CD213a1, internalization of IL-13
Ligand/Receptor
IL-13
Cell Type
B cells, Fibroblasts
Biology Area
Cell Biology, Immunology
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors
Antigen References

1. Mitchell J, et al. 2010. Curr. Opin. Investig Drugs. 11:527.
2. Strober W, et al. 2009. Curr. Mol. Med. 9:740.
3. Tabata Y and Khurana Hershey GK. et al. 2007. Curr. Allergy Asthma Rep. 7:338.

Gene ID
3598 View all products for this Gene ID
UniProt
View information about CD213a2 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 2    Revision Date: 03/21/2014

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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