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- Clone
- JOVI.1 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- T cell receptor beta constant 1, TRBC1
- Isotype
- Mouse IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Human peripheral blood lymphocytes were stained with purified anti-human TCR Cβ1 (clone JOVI.1) (left) or purified mouse IgG2a, κ isotype control (right) followed by PE anti-mouse IgG. Cells were costained with anti-human CD3 APC.
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 383502 | 100 µg | $265 | ||||
TRBC1 is a 20 kD protein constant region of the T cell receptor also known as T cell receptor beta constant 1. It is expressed on a fraction of TCRαβ T cells on the beta chain of the T Cell receptor. The constant region expression of clones is notable as a marker for T Cell disease development by clonality detection.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Transgenic mouse lymphocytes expressing human Vβ3-Cβ1 TCR
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
Clone JOVI.1 can interfere binding of clone IP26 on target cells.
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Application References
(PubMed link indicates BioLegend citation) -
- Viney, J L et al. 1992. Hybridoma. 11:701-13.
- Horna, Pedro et al. 2021. Int J Mol Sci. 22:1817.
- RRID
-
AB_2924585 (BioLegend Cat. No. 383502)
Antigen Details
- Structure
- Predicted 20 kD Ig-like protein
- Distribution
-
T lymphocytes
- Cell Type
- Leukemia, Lymphocytes, T cells, Thymocytes
- Biology Area
- Cancer Biomarkers, Cell Biology, Immunology
- Molecular Family
- TCRs
- Antigen References
-
- Minden, M D and T W Mak. 1986. Blood. 68:327-36.
- Davis, M M et al. 1997. Ciba Found Symp. 204:94-100.
- Maciocia, Paul M et al. 2017. Nat Med. 23:1416-23.
- Gene ID
- 28639 View all products for this Gene ID
- UniProt
- View information about TCR Cbeta1 on UniProt.org
Related FAQs
Other Formats
View All TCR Cβ1 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-human TCR Cβ1 | JOVI.1 | FC |
| APC anti-human TCR Cβ1 | JOVI.1 | FC |
| PE anti-human TCR Cβ1 | JOVI.1 | FC |
| PerCP/Cyanine5.5 anti-human TCR Cβ1 | JOVI.1 | FC |
| FITC anti-human TCR Cβ1 | JOVI.1 | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human TCR Cβ1
Human peripheral blood lymphocytes were stained with purifie... -
APC anti-human TCR Cβ1
Human peripheral blood lymphocytes were stained with anti-hu... -
PE anti-human TCR Cβ1
Human peripheral blood lymphocytes were stained with anti-hu... -
PerCP/Cyanine5.5 anti-human TCR Cβ1
Human peripheral blood lymphocytes were stained with anti-hu... -
FITC anti-human TCR Cβ1
Human peripheral blood lymphocytes were stained with anti-hu...
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