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BioLegend T Helper Types
T Helper Cell Fates
CD4 T helper cells are the primary orchestrators of the adaptive immune response, mediating a variety of cellular and humoral responses against pathogens and cancer. Although they lack any capacity to directly kill or engulf pathogens, they are powerful activators of effector cells such as macrophages, cytotoxic T cells, and B cells. On the other hand, regulatory T cells (Tregs) are potent suppressors of the immune response important in limiting the immune reaction. Recent advances have led to the discovery of a diverse set of T helper subsets, each with unique functions. Explore them here...
Naïve T cells are also known as resting T cells that circulate in the blood, waiting to be activated by antigen presenting cells. They are characterized by a few cell surface molecules such as CD4, CD45RA, CD62L, and CCR7. Naive cells can be fully activated by antigen presenting cells, including Dendritic cells, Macrophages, and B cells, that deliver stimulatory signals through the TCR and costimulatory signals through CD28.
Treg Cell Th1 Cell Th2 Cell Th9 Cell Th17 Cell Th22 Cell Thf Cell
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BioLegend Tools for T Helper Cell Research
Fluorophore-Conjugated Antibodies LEAF™ (Low Endotoxin, Azide-Free) Antibodies ELISAs Recombinant Proteins Purified antibodies Custom Products and Services
For use in flow cytometry or microscopy to detect surface or intracellular targets. For use in functional assays such as cell activation, costimulation, blocking, or neutralization of cytokines. For detecting secreted proteins such as cytokines, chemokines, growth factors or other soluble factors. For use in bioassays or as ELISA standards. For use in ELISA, ELISPOT, IHC, IF, CyTOF, or western blot detection in combination with the appropriate secondary reagents. For any research needs that are outside of our catalog.
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