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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
COA:
Application References:
1. Robinson AP, et al. 1986. Immunology 57:527.
LOU rat splenocytes stained with OX-52 purified, followed by anti-muse IgG biotin and SAV-PE
Rat CD6 is a membrane molecule of 95-120 kD, expressed primarily on all the T lymphocytes of alpha/beta or gamma/delta TCR. Rat NK cells express low levels of CD6. In immunoprecipitation studies, CD6 was found to co-precipitate with highly phorsphorylated CD5, and other protein kinases, such as Lck, Fyn, ZAP70, and Itk.
Other Names:
OX-52 antigen, T12
Structure:
A membrane protein of about 100 kD. 665 amino acids.
Distribution:
Positive on all peripheral T lymphocytes and thymocytes expressing either ab and gd T cell receptors. Rat NK cells express low level of CD6.
Interaction:
Rat CD6 associates with protein kinases of different families, including CD5, the Src kinases of Lck and Fyn, the ZAP-70 and Tec family kinase Itk.
Bioactivity/Activities:
Important role in the regulation of phosphorylation of CD5 and other molecules.
Antigen References:
1. Castro MAA, et al. 2003. J. Leukoc. Biol. 75:183.
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This data display is provided for general comparisons between formats. Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors. If you need assistance with selecting the best format contact our expert technical support team.
Purified anti-rat CD6
LOU rat splenocytes stained with OX-52 purified, followed by anti-muse IgG biotin and SAV-PE
Alexa Fluor® 647 anti-rat CD6
LOU rat splenocytes stained with OX-52 Alexa Fluor® 647
