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Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 μl per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.
COA:
Jurkat cell extract was resolved by electrophoresis, transferred to nitrocellulose, and probed with rabbit anti-PI3K p110 delta antibody. Proteins were visualized using a donkey anti-rabbit secondary conjugated to HRP and a chemiluminescence detection system.
PI3K p110 delta (phosphatidylinositol-4,5-biphosphate 3-kinase catalytic subunit delta isoform) is a member of the PI3/PI4 kinase family containing a B-Zip domain. This 110 kD protein autophosphorylates, but does not phosphorylate p85 like PI3K p110 δ. PI3K p110 delta exhibits a broad phosphoinositide lipid substrate specificity and is required for directional movement in neutrophils, and is involved in B and T cell receptor complex signaling. This isoform interacts with SH2/SH3 domain-containing p85 adaptor proteins and GTP-bound Ras and consists of catalytic p110 and regulatory p85 subunits and is activated by IL-3, IL-4 and SCF. PI3K is modified by phosphorylation. The Poly6049 antibody recognizes human PI3K p100 delta and has been shown to be useful for Western blotting.
Autophosphorylates, does not phosphorylate p85 like PI3K p110 δ. Exhibits broad phosphoinositide lipid substrate specificity; required for directional movement in neutrophils, involved in B and T cell receptor complex signaling
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Purified anti-PI3K p110 delta
Jurkat cell extract was resolved by electrophoresis, transferred to nitrocellulose, and probed with rabbit anti-PI3K p110 delta antibody. Proteins were visualized using a donkey anti-rabbit secondary conjugated to HRP and a chemiluminescence detection system.
