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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
COA:
Application References:
1. Nakae S, et al. 2007. Blood doi:10.1182/blood-2006-11-058800.
Mouse Tim-3 transfected cells stained with purified RMT3-23, followed by anti-rat IgG FITC
Tim-3 is a transmembrane protein also known as T cell immunoglobulin and mucin domain containing protein-3. Tim-3 is expressed at high levels on Th1 lymphocytes and CD11b+ macrophages. Tim-3 has also been shown to exist as a soluble protein. Cells expressing Tim-3 are present at high levels in the CNS of animals at the onset of experimental autoimmune encephalomyelitis (EAE), a disease mediated by lymphocytes secreting Th1-like cytokines. Tim-3 has been proposed to inhibit Th1-mediated immune responses and promote immunological tolerance.
Other Names:
T cell immunoglobulin and mucin domain containing 3 protein, hepatitis virus cellular receptor 2
Structure:
Transmembrane protein containing immunoglobulin domain and mucin-like domain; predicted molecular weight 31 kD. Can exist as a soluble form lacking mucin and transmembrane domains
Distribution:
Expressed on activated Th1 lymphocytes and CD11b+ macrophages
Function:
May play a role in the development of immune responses and the development of Th1-mediated responses
Ligand Receptor:
Putative ligand on resting CD4+ lymphocytes
Antigen References:
1. Sabatos CA, et al. 2003. Nat. Immunol. 4:1102. 2. Sanchez-Fueyo A, et al. 2003. Nat. Immunol. 4:1102. 3. Kuchroo VK, et al. 2003. Nat. Rev. Immunol. 3:454. 4. Mooney L, et al. 2002. Nature 415:536.
*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/terms). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.
This data display is provided for general comparisons between formats. Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors. If you need assistance with selecting the best format contact our expert technical support team.
Purified anti-mouse Tim-3
Mouse Tim-3 transfected cells stained with purified RMT3-23, followed by anti-rat IgG FITC
PE anti-mouse Tim-3
Mouse Tim-3 transfected cells stained with RMT3-23 PE
