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Purified anti-mouse Tim-2 Antibody
Purified anti-mouse Tim-2 Antibody
129001 50 µg $105.00     
Product Details
Clone: F37-2C4
Isotype: Mouse IgG1, κ
Isotype Control:Purified Mouse IgG1, κ Isotype Ctrl
Reactivity: Mouse
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted at 4 °C.
Application:

FC - Quality tested
IF, ELISA - Reported in the literature
Recommended Usage:

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance in each application.
COA:
Enter Lot#:   
 Mouse Tim-2 transfected cells stained
Mouse Tim-2 transfected cells stained with purified F37-2C4, followed by biotinylated anti-mouse IgG and Sav-PE


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Description:

Tim-2 is a transmembrane protein known as T cell immunoglobulin and mucin domain containing protein-2. It is expressed on activated T cells and preferentially on differentiated Th2 cells. Sema4A is the ligand of Tim-2. A blockade of Tim-2/Tim-2 ligand interaction results in T cell hyperproliferation and Th2 cytokine production. Tim-2 plays a critical role in the development of atopic disease and other Th2-biased immune responses.
Other Names: T cell immunoglobulin and mucin domain containing protein-2
Structure: Transmembrane protein containing immunoglobulin domain and mucin-like domain; predicted molecular weight 33 kD
Distribution: Developmentally regulated; highly expressed in embryonic development at the 8-cell stage and blastocyst. Expressed on activated T lymphocytes.
Ligand Receptor: Sema4A, H-ferritin
Antigen
References:

1. Kuchroo VK, et al. 2003. Nat. Rev. Immunol. 3:454.
2. Kumanogoh A, et al. 2002. Nature 419:629.
3. Chakravarti S, et al. 2005. J. Exp. Med. 202:437
GeneID: 171284
Latest Publications: View the latest Tim-2 articles on HighwirePress.com
UniProt: View information about Tim-2 on UniProt.org
Keywords: Purified anti-mouse Tim-2, F37-2C4, Purified, T cell immunoglobulin and mucin domain containing protein-2, Mouse, Immunology, Antibodies
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Compare Data Across All Formats
This data display is provided for general comparisons between formats. Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors. If you need assistance with selecting the best format contact our expert technical support team.
  • Purified anti-mouse Tim-2
    Mouse Tim-2 transfected cells stained

    Mouse Tim-2 transfected cells stained with purified F37-2C4, followed by biotinylated anti-mouse IgG and Sav-PE

  • PE anti-mouse Tim-2
    Mouse Tim-2 transfected cells stained

    Mouse Tim-2 transfected cells stained with F37-2C4 PE

  • Alexa Fluor® 647 anti-mouse Tim-2
    Mouse Tim-2 transfected cells stained

    Mouse Tim-2 transfected cells stained with F37-2C4 Alexa Fluor® 647

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