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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
COA:
Application References:
1. Meyers JH, et al. 2005. Nat. Immunol. 6:455. 2. Nakae S, et al. 2007. Blood doi:10.1182/blood-2006-11-058800. 3. Yamanishi Y, et. al. 2010. J. Exp. Med. 207:1501. (FC)
Mouse Tim-1 transfected cells stained with purified RMT1-4, followed by anti-rat IgG FITC
Tim-1 is a transmembrane protein also known as T cell immunoglobulin and mucin domain containing protein-1 and hepatitis virus cellular receptor 1. It is developmentally expressed at high levels in the blastocyst. Tim-1 is expressed on activated CD4+ lymphocytes especially on Th2 cells and has been implicated to play a critical role in the development of atopic disease and other Th2-biased immune responses. Tim-1 is hepatitis A virus receptor in humans. Tim-4 is the endogenous ligand of Tim-1. The interaction of Tim-1 and Tim-4 is involved in costimulation of T cell proliferation. Tim-1 is an endogenous ligand for LMIR5/CD300b.
Other Names:
T cell immunoglobulin and mucin domain containing protein-1, T cell and airway phenotype regulator (Tapr), hepatitic virus cellular receptor 1
Structure:
Transmembrane protein containing immunoglobulin domain and mucin-like domain; predicted molecular weight 33 kD.
Distribution:
Developmentally regulated; highly expressed in embryonic development in blastocysts. Expressed on activated CD4+ lymphocytes, especially Th2 cell lines.
Function:
Binds hepatitis virus, may play a critical role in immune responses and the development of atopic diseases (in particular airway hyperreactivity).
Ligand Receptor:
Binds hepatitis A virus in humans, Tim-4, LMIR5/CD300b
Antigen References:
1. McIntire JJ, et al. 2001. Nature Immunol. 2:1109. 2. Kuchroo VK, et al. 2003. Nat. Rev. Immunol. 3:454. 3. Wills-Karp M, et al. 2001. Nat. Rev. Immunol. 1:69. 4. Meyers JH, et al. 2005. Nat. Immunol. 6(5):455.
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This data display is provided for general comparisons between formats. Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors. If you need assistance with selecting the best format contact our expert technical support team.
Purified anti-mouse Tim-1
Mouse Tim-1 transfected cells stained with purified RMT1-4, followed by anti-rat IgG FITC
Biotin anti-mouse Tim-1
Mouse Tim-1 transfected cells stained with biotinylated RMT1-4, followed by Sav-PE
PE anti-mouse Tim-1
Mouse Tim-1 transfected cells stained with RMT1-4 PE
