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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
COA:
Application Notes:
Additional reported applications (for the relevant formats) include: in vitro blocking of antigen-induced proliferation of Vβ13+ T cells 1 and in vivo depletion of Vβ13+ T cells1.
Application References:
1. Zaller DM, et al. 1990. J. Exp. Med. 171:1943. (Block)
BALB/c splenocytes stained with MR12-4 PE and purified CD3 conjugated with APC
Vβ13 T cell receptor (TCR Vβ13) is a variant of TCR β chain that along with TCR α chain forms the TCR heterodimer. In association with the CD3 complex, TCR α/β is responsible for antigen recognition in the MHC-Peptide complex and initiation of T cell-mediated immune responses. The most frequently β chains found in the immune response to myelin basic protein (MBP) in B10.PL mice are Vβ13 and Vβ8.2.
Other Names:
Vβ13 T-cell receptor, T cell receptor beta 13
Structure:
Member of the immunoglobulin superfamily, Vβ13 is a variant of the TCR β chain which associates with the TCR α chain to form the TCR heterodimer.
Distribution:
Expressed on a subset of TCR αβ+ T cells.
Function:
Recognition of peptides presented by the MHC molecules, responsible for T cell mediated immune responses.
Ligand Receptor:
MHC-Peptide complex
Antigen References:
1. Zaller DM, et al. 1990. J. Exp. Med. 171:1943. 2. Gentile F, et al. 2004. Immunology 112:13. 3. Lode HN, et al. 1999. P. Natl. Acad. Sci. USA 96:8591.
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This data display is provided for general comparisons between formats. Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors. If you need assistance with selecting the best format contact our expert technical support team.
Purified anti-mouse TCR Vβ13
BALB/c splenocytes stained with MR12-4 PE and purified CD3 conjugated with APC
PE anti-mouse TCR Vβ13
BALB/c splenocytes stained with MR12-4 PE and CD3 APC
