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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
COA:
Application Notes:
Additional reported applications (for the relevant formats) include: Western blot1.
Application References:
1. Watarai H, et al. 2008. Proc. Natl. Acad. Sci. USA 105:2993. (WB)
C57BL/6 mouse splenocytes activated overnight with CpG-A and stained with B220 FITC and purified 4A6 conjugated with PE (top) or mouse IgG2a PE isotype control (bottom). The data shown is from the B220+CD11c+ cell population.
PDC-TREM, also known as plasmacytoid dendritic cell (PDC) -specific receptor, is a member of the TREM receptor family. It is a transmembrane protein composed of an extracellular region with one V-type Ig domain, a transmembrane region with a lysine residue, and a cytoplasmic domain with no recognized signaling motifs. The lysine present in the transmembrane region allows PDC-TREM to form a complex with DAP12 and Plexin-A1. PI3K and Erk 1/2 are involved in the signal transduction of this complex. PDC-TREM is expressed in TLR-activated PDCs and is involved in the production of IFN-α.
Other Names:
Plasmacytoid dendritic cell-specific receptor
Structure:
Member of the TREM receptor family. Type I protein composed of an extracellular region with a single V-type Ig domain, a transmembrane domain with a lysine residue and a cytoplasmic domain with no recognized signaling motifs.
Distribution:
Expressed on TLR activated plasmacytoid dendritic cells (PDC)
Function:
Signal transduction, induces the production of IFN-α
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This data display is provided for general comparisons between formats. Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors. If you need assistance with selecting the best format contact our expert technical support team.
Purified anti-mouse PDC-TREM
C57BL/6 mouse splenocytes activated overnight with CpG-A and stained with B220 FITC and purified 4A6 conjugated with PE (top) or mouse IgG2a PE isotype control (bottom). The data shown is from the B220+CD11c+ cell population.
PE anti-mouse PDC-TREM
C57BL/6 mouse splenocytes activated overnight with CpG-A and stained with B220 FITC and 4A6 PE (top) or mouse IgG2a PE isotype control (bottom). The data shown is from the B220+CD11c+ cell population.
