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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
COA:
Application References:
1. Moriyama Y, et al. 2008. Int. Immunol. 20:763.
FD1/CHO (mouse DLL1 transfected cel l line) stained with purified HMD1-3, followed by anti-Armenian hamster IgG PE
The Notch receptors and their ligands are highly conserved from invertebrates to mammals. The Delta-like 1 (DLL1) is one of the four or five Notch ligands identified. The binding to Notch receptor results in the proteolysis of Notch and movement of intracellular portion of Notch into the nucleus.This translocation triggers a series of signaling process. Delta-like 1 is reported to be essential for the maintenance of marginal zone B cells in normal mice, and engagement of Notch 1 by DLL1 promotes differentiation of B lymphocytes to antibody-secreting cells.
Other Names:
Dll 1, Dll-1
Structure:
A single pass transmembrane protein consisting of a large extracellular N-terminal which includes the DSL domain, followed by a tandem array of EGF-like repeats (ELRs). After a single transmembrane domain (TM) is a novel intracellular domain.
Function:
The Notch receptors and their ligands are highly conserved signaling molecules throughout development. They regulate cell fate decision for various cell development, including myogenesis, neurogenesis, and lymphocyte development.
Ligand Receptor:
Notch receptors
Antigen References:
1. Ehebauer MT, et al. 2006. Biochem. J. 392:13. 2. Shimizu K, et al. 2000. Mol. Cell. Biology 20:18. 3. Parks AL, et al.2006. Genetics 174:1947. 4. Santos MA, et al. 2007. P. Natl. Acad. Sci. USA 104:15454.
*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/terms). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.
This data display is provided for general comparisons between formats. Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors. If you need assistance with selecting the best format contact our expert technical support team.
Purified anti-mouse DLL1
FD1/CHO (mouse DLL1 transfected cel l line) stained with purified HMD1-3, followed by anti-Armenian hamster IgG PE
Biotin anti-mouse DLL1
FD1/CHO transfected cells stained with HMD1-3 biotin, followed by Sav-PE
LEAF™ Purified anti-mouse DLL1
FD1/CHO transfected cells stained with LEAF™ purified HMD1-3, followed by anti-Armenian Hamster IgG-PE
PE anti-mouse DLL1
LPS-stimulated BALB/c peritoneal macrophages (Day 2) stained with HMD1-3 PE
Alexa Fluor® 647 anti-mouse DLL1
FD1/CHO (mouse DLL1) transfected cell line stained with HMD1-3 Alexa Fluor® 647
APC anti-mouse DLL1
FD1/CHO (mouse DLL1) transfected cell line stained with HMD1-3 APC
