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Purified anti-mouse CD93 (AA4.1, early B lineage) Antibody
Purified anti-mouse CD93 (AA4.1, early B lineage) Antibody
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
COA:
Application References:
1. McKearn JP, et al. 1984. J. Immunol. 132:332.
C57BL/6 mouse bone marrow cells stained with CD45R/B220 (RA3-6B2) APC and AA4.1 PE
C57BL/6 mouse bone marrow cells stained with CD45R/B220 (RA3-6B2) APC and rat IgG2b (RTK4530) PE isotype control
CD93 is a 130-140 kD C-type lectin-like type I transmembrane protein, also known as complement component 1, q subcomponent (C1qR1), C1qRp collectin receptor (C1qRp), or AA4 antigen. It is a receptor expressed on immature B lymphocytes, hematopoietic progenitors and stem cells in adult bone marrow, fetal liver, and the embryonic yolk sac. CD93 expression levels on splenic immature/transitional B cells is much lower than in bone marrow. It is reinduced during plasma cell differentiation and plays an important role in maintaining plasma cells in bone marrow niches. Immature dendritic cells express CD93 and down-regulate this molecule upon maturation, suggesting they play a role in uptake of particles. CD93 is also expressed on monocytes, macrophages, and endothelial cells. Macrophages from CD93 (-/-) mice had a significant phagocytic defect in the clearance of apoptotic cells <i>in vivo</i>, indicating CD93 may contribute to the <i>in vivo</i> clearance of dying cells. The idea that CD93 binds to C1q remains controversial.
Other Names:
AA4.1, C1qRp, Early B lineage antigen
Structure:
A 130-140 kD C-type lectin like type I transmembrane protein, also known as complement component 1, q subcomponent (C1qR1), C1qRp collectin receptor (C1qRp), or AA4 antigen.
Distribution:
Expressed during immature B lymphocytes, hematopoietic progenitors and stem cells in bone marrow, immature dendritic cells, monocytes, macrophages, and endothelial cells.
Function:
CD93 plays an important role in maintaining of plasma cells in bone marrow niches. It may play a role in uptake of particles by DC and the in vivo clearance of dying cells by macrophages.
Antigen References:
1. Steinberger P, et al. 2002. J. Leukoc. Biol. 71:133. 2. Chevrier S, et al. 2009. Proc. Nat. Acad. Sci. USA 106:3895. 3. Norsworthy PJ, et al. 2004. J. Immunol. 172:3406. 4. Li YS, et al. 1996. Immunity 5:527. 5. Szilvassy SJ, et al. 1993. Blood 81:2310.
*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/terms). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.
This data display is provided for general comparisons between formats. Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors. If you need assistance with selecting the best format contact our expert technical support team.
FITC anti-mouse CD93 (AA4.1, early B lineage)
C57BL/6 mouse bone marrow cells stained with CD45R/B220 PE and AA4.1 FITC
Purified anti-mouse CD93 (AA4.1, early B lineage)
C57BL/6 mouse bone marrow cells stained with CD45R/B220 (RA3-6B2) APC and AA4.1 PE
C57BL/6 mouse bone marrow cells stained with CD45R/B220 (RA3-6B2) APC and rat IgG2b (RTK4530) PE isotype control
PE anti-mouse CD93 (AA4.1, early B lineage)
C57BL/6 mouse bone marrow cells stained with CD45R/B220 (RA3-6B2) APC and AA4.1 PE
C57BL/6 mouse bone marrow cells stained with CD45R/B220 (RA3-6B2) APC and rat IgG2b (RTK4530) PE isotype control
PE/Cy7 anti-mouse CD93 (AA4.1, early B lineage)
C57BL/6 bone marrow cells stained with AA4.1 PE/Cy7 and CD45R/B220 APC
C57BL/6 bone marrow cells stained with rat IgG2b PE/Cy7 isotype control and CD45R/B220 APC
APC anti-mouse CD93 (AA4.1, early B lineage)
Balb/c bone marrow cells stained with CD45R/B220 (RA3-6B2) PE and AA4.1 APC
Balb/c bone marrow cells stained with CD45R/B220 (RA3-6B2) PE and rat IgG2b, κ APC isotype control
PerCP/Cy5.5 anti-mouse CD93 (AA4.1, early B lineage)
C57BL/6 bone marrow cells stained with CD45R/B220 (RA3-6B2) APC and AA4.1 PerCP/Cy5.5
C57BL/6 bone marrow cells stained with CD45R/B220 (RA3-6B2) APC and rat IgG2b PerCP/Cy5.5 isotype control
