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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
COA:
Application Notes:
Additional reported (for relevant formats) applications include: immunoprecipitation1, 2, Western Blot1, 2, and immunohistochemical staining of frozen sections2 and paraformaldehyde-fixed paraffin-embedded sections3.
Application References:
1. Silva RP, et al. 1999. Biochem. J. 338:687. (IP, WB) 2. Rabinowitz SS, et al. 1991. J. Exp. Med. 174:827. (IP, WB, IHC) 3. Wu J, et al. 2008. P. Natl. Acad. Sci. USA 105:16934. (IHC) 4. Kayama H, et al. 2012. PNAS. 109:5010. PubMed.
Mouse CD68, also known as macrosialin, is an 85-115 kD member of the lysosomal-associated membrane protein (LAMP) family. It is a heavily glycosylated and predominantly intracellular protein, mainly in late endosomes. Macrosialin is the murine homolog to the human macrophage glycoprotein CD68. It is expressed on tissue macrophages, Langerhans cells and at low levels on dendritic cells. Lamp proteins may have functions relating to cell-cell interaction or cell-ligand interaction. The biological function of CD68 is not completely understood.
Other Names:
Macrosialin
Structure:
A member of the lysosomal-associated membrane protein (lamp) family.
Distribution:
Expressed on tissue macrophages, Langerhans cells, and at low levels on dendritic cells.
Function:
Involved in cell-cell interaction or cell-ligand interaction, still not completely understood.
Antigen References:
1. Ramprasad MP, et al. 1996. Proc. Natl. Acad. Sci.USA 93:14833. 2. Smith MJ, et al. 1987. J. Cell. Sci. 87:113.
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This data display is provided for general comparisons between formats. Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors. If you need assistance with selecting the best format contact our expert technical support team.
