Welcome to BioLegend’s one-of-a-kind advanced search. Search by any one of the single fields below or narrow down your searches by using multiple parameters. Looking for an anti-mouse NK cell antibody for IHC? Or looking for a FITC-conjugated antibody against a human marker for dendritic cells to use for flow cytometry? Only BioLegend’s advanced search can provide you with the best answers. If you have further questions, please contact our technical service team at 858-768-5801.
Use this document lookup tool to find Current Product Datasheets, Certificates of Analysis, or MSDS for any antibody products you have purchased from BioLegend.
Use the search box below to perform a site search of BioLegend.com powered by Google™.
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
COA:
Application Notes:
Additional reported applications (for the relevant format) include: inhibition of cell adhesion and cytokine production1,2.
Application References:
1. Miyake S, et al. 1994. Eur. J. Immunol. 24:2000. (FC, Block) 2. Tanaka T, et al. 1995. Int. Immunol. 7:1183. (Block)
C1300 (mouse adenocarcinoma cell line) cells were stained with purified CD49a (clone HMα1, filled histogram) or Armenian hamster IgG (open histogram), followed by anti-hamster IgG PE.
CD49a is a 1179 aa, type I transmembrane glycoprotein also known as α1 integrin, VLA-1 α chain, or integrin α1. It associates antibody v042010 with CD29 (β1 integrin) to form the VLA-1 complex, a collagen IV and alminin-1 receptor that is expressed on activated T cells, smooth muscle cells, endothelial cells, neuronal cells, fibroblasts, and mesenchymal cells. CD49a is an adhesion molecule and is involved in the regulation of leukocyte migration, T cell proliferation, and cytokine production.
Other Names:
Very late antigen 1 (VLA1), integrin alpha 1 (ITGA1)
Structure:
1179 aa, type I transmembrane glycoprotein
Distribution:
Endothelial cells, fibroblasts, activated T cells
Function:
Leukocyte adhesion and homing; costimulation
Ligand Receptor:
Collagens, laminin
Antigen References:
1. Barczyk M, et al. 2010. Cell Tissue Res. 339:269.
*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/terms). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.
This data display is provided for general comparisons between formats. Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors. If you need assistance with selecting the best format contact our expert technical support team.
Purified anti-mouse CD49a
C1300 (mouse adenocarcinoma cell line) cells were stained with purified CD49a (clone HMα1, filled histogram) or Armenian hamster IgG (open histogram), followed by anti-hamster IgG PE.
PE anti-mouse CD49a
C1300 (mouse neuroblastoma cell line) cells were stained with CD49a (clone HMα1) PE (filled histogram) or Armenian hamster IgG PE isotype control (open histogram).
