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Each lot of this antibody is quality control tested by ELISA. For ELISA, the suggested use of this reagent is 10 µg/ml. It is recommended that the reagent be titrated for optimal performance for each application.
COA:
Application Notes:
Additional reported applications (for relevant formats) include: in vivo blocking of LIGHT activity in a DSS-induced acute intestinal inflammation model1; in vitro blocking of the LIGHT-induced expression of CXCL8/CXCL2 by BFS-1 and A375 cells1, and immunoprecipitation1.
Application References:
1. Jungbeck M, et al. 2009. J. Immunol. 128:451.
Description:
CD258, also known as LIGHT, belongs to the tumor necrosis factor (TNF) superfamily. CD258 is a homotrimer composed of type II single-pass chains. The cleavage of this molecule from the cell surface results in a soluble form of LIGHT. CD258 stimulates T cell proliferation, CTL activity, Th1 cytokine production and induces apoptosis in some tumor lines. CD258 is expressed by T cells, NK cells, macrophages and platelets. The receptors of LIGHT are HVEM, LTβR and DCR3. CD258 has an important role in the cell-mediated immune response and in graft versus host disease.
Other Names:
LIGHT, TNFSF14, LTγ, HVEM-L, Ly113, TR2 ligand
Structure:
Homotrimer composed of a single-pass type II membrane protein, soluble form after cleavage. Belongs to the tumor necrosis factor (TNF) superfamily.
Distribution:
T cells, NK, macrophages and platelets
Function:
Stimulates T cell proliferation, CTL activity and Th1 cytokine production, induce apoptosis in some tumor lines
Ligand Receptor:
HVEM, LTβR, DCR3
Antigen References:
1. Tama K, et al. 2000. Nat. Med. 6:283. 2. Cohavey O, et al. 2005. J. Immunol. 174:646. 3. Madge LA, et al. 2008. J. Immunol. 180:3467.
*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/terms). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.
