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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
COA:
Application References:
1. Sano H, et al. 2001. Circulation 103:2955.
Mouse fibroblast NIH/3T3 cells stained with APB5 PE
Platelet-derived growth factor receptor-β (PDGFR-β), CD140b, is one of two receptors for platelet-derived growth factors (PDGFs) and binds to all isoforms of PDGFs. PDGFRβ is a receptor tyrosine kinase that forms homodimers or heterodimers on the surface upon ligand binding and phosphorylates substrates. PDGFRs consist of either homodimers of α/α, β/β, or heterodimers of α/β. PDGF receptors, α and β, are single glycoproteins with intracellular tyrosine kinase domain. Their ligand, PDGF, is a mitogen for connective tissue and glial cells. CD140b is expressed on embryonic tissues and mesenchymal-derived cells adult mice. PDGF plays a role in wound healing and acts as a chemoattractant for fibroblasts, smooth muscle cells, glial cells, monocytes, and neutrophils.
Beta chain of the platelet-derived growth factor receptor, a receptor tyrosine kinase that forms homo- or hetero-dimers on the surface after ligand binding.
Distribution:
Expressed on embryonic tissues and mesenchymal-derived cells of adult mouse.
Function:
Play a role in wound healing and act as a chemoattractant for fibroblasts, smooth muscle cells, glial cells, monocytes and neutrophils.
Ligand Receptor:
PDGFs
Antigen References:
1. Soriano P, et al. 1994. Genes Dev. 8:1888 2. Takakura N, et al. 1996. J Invest Dermatol. 107:770 3. Yarden Y, et al. 1986. Nature 323:226
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This data display is provided for general comparisons between formats. Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors. If you need assistance with selecting the best format contact our expert technical support team.
Purified anti-mouse CD140b
Mouse fibroblast NIH/3T3 cells stained with APB5 PE
C57BL/6 splencoytes stained with APB5 PE
PE anti-mouse CD140b
Mouse fibroblast NIH/3T3 cells stained with APB5 PE
C57BL/6 splencoytes stained with APB5 PE
APC anti-mouse CD140b
Mouse fibroblast NIH/3T3 cells stained with APB5 APC
Biotin anti-mouse CD140b
Mouse fibroblast NIH/3T3 cells stained with biotinylated APB5, followed by Sav-PE
