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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
COA:
Application Notes:
Additional reported applications include: immunoprecipitation, Western blotting, and immunofluorescence histochemistry or immunohistochemistry of acetone-fixed frozen sections2-4.
Application References:
1. Ge AZ and Butcher EC. 1994. Gene 138:201. 2. Baluk P, et al. 2003. Am. J. Pathol. 163:1801. (IHC) 3. Takahashi T, et al. 2003. Mol. Cell Biol. 23:1817. (IHC) 4. Savinov AY, et al. 2003. J. Exp. Med. 197:643. (IHC)
Description:
CD105 is a 90 kD homodimeric type I integral membrane glycoprotein, also known as endoglin. It is expressed on endothelial cells (especially on angiogenic endothelial cells) and up-regulated by hypoxia, activated monocytes, macrophages, bone marrow stromal cells, and some cytotrophoblasts. CD105 is a receptor for TGF-ß1, TGF-ß3 and modulates TGF-ß signaling by interacting with TGF-ß receptors I and/or II. CD105 also binds other growth factors such as actvin A, BMP-2 and -7. CD105 has been show to be a useful marker for identifying proliferating endothelium involved in tumor angiogenesis and can be used for tumor imaging, prognosis, as well as has therapeutic potential for some solid tumors and other angiogenic diseases.
Other Names:
Endoglin
Structure:
Type I integral membrane protein, , homodimer, TGF-ß type III receptor family member
Distribution:
Endothelial cells, activated monocytes, macrophages, stromal cells, some cytotropholast
Function:
Suppress TGF-ß signaling, angiogenesis
Ligand Receptor:
TGF-ß1, TGF-ß3
Antigen References:
1. Gougos A and M. Letarte 1988. J. Immunol. 141:1925. 2. Cheifetz S, et al. 1992. J. Bio. Chem. 267:19027. 3. Barbara NP, et al. 1999. J. Bio. Chem. 274:584. 4. Lastres P, et al. 1992. Eur. J. Immunol. 22:393. 5. Duff S, et al. 2003. FASEB J. 17:984. 6. Warrington K, et al. 2005. Anticancer Res. 25:185
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