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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ≤0.06 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
COA:
Mouse B7-H4 transfected 293E cells stained with clone 9 PE
B7-H4 is a newly discovered B7 family member that negatively regulates T cell immunity by inhibiting of T cell proliferation, cytokine production, and cell cycle progression. In vitro, B7-H4 inhibits CD4+ and CD8+ T cell proliferation, cytokine production, and generation of alloreactive cytotoxic T-cells (CTLs). In vivo, blockade of endogenous B7-H4 by specific monoclonal antibody promotes T cell responses. A new function of B7-H4 was reported as an important negative regulator of innate immunity through growth inhibition of neutrophils. It was reported that B7-H4 does not constitutively expressed on peripheral tissues but could be induced to express on T cells, B cells, macrophages, and dendritic cells. B7-H4 is expressed on some tumor cancer cells. The role of B7-H4 in tumor progression may be to transform precancerous cells and then protect them from immunosurveillance. Although B- and T- lymphocyte attenuator (BTLA) was proposed to be the receptor for B7-H4, further studies are needed to identify the inhibitory receptor of B7-H4.
Other Names:
B7H4, B7S1, B7-S1, B7x
Structure:
Belong to the B7 family of costimulatory proteins and contain two extracellular Ig-like domains.
Distribution:
Induced to express on T cells, B cells, macrophages, and dendritic cells. It is also expressed on some tumor cancer cells.
Function:
Inhibit T cell activation, cell cycle progression, and cytokine production.
Ligand Receptor:
A putative receptor on T cells
Antigen References:
1. Prasad DV, et al. 2003. Immunity18(6):863 2. Zang X, et al. 2003. Proc Natl Acad Sci USA. 2003. 100:10388 3. Yi KH, et al. 2009. Immunol. Rev. 229 (1):145
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This data display is provided for general comparisons between formats. Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors. If you need assistance with selecting the best format contact our expert technical support team.
PE anti-mouse B7-H4 (B7S1, B7X)
Mouse B7-H4 transfected 293E cells stained with clone 9 PE
Purified anti-mouse B7-H4 (B7S1, B7X)
Mouse B7-H4 transfected 293E cells stained with clone 9 PE
