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Purified anti-human IL-1β Antibody
Purified anti-human IL-1β Antibody
511702 500 µg ¥48,000     

Product Details

Clone: H1b-98
Isotype: Mouse IgG1, κ
Reactivity: Human
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted at 4°C.
Application:

ELISA Detection - Quality tested

Recommended Usage:

Each lot of this antibody is quality control tested by ELISA assay. For use as an ELISA detection antibody, a concentration range of 1-4 µg/ml is recommended. To obtain a linear standard curve, serial dilutions of human IL-1β protein ranging from 250 to 2 pg/ml are recommended for each ELISA plate.

COA:
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Description:

IL-1 refers to two proteins, IL-1α and IL-1β which are the products of distinct genes, but which are recognized by the same cell surface receptors. IL-1β is a potent immuno-modulator which mediates a wide range of immune and inflammatory responses including the activation of B and T cells. 

Other Names: Interleukin-1β, H1, OAF, Catabolin, IFNb-inducing factor(il-1b,il1b)
Structure: Cytokine; 17.3 kD (Mammalian)
Regulation: Upregulated by TNF-α, IFN-α, IFN-β, IFN-γ, bacterial endotoxins, viruses, mitogens, antigens; downregulated by IL-6, lipoproteins, lipids, and α2-macroglobulin
Cellular Sources: Monocytes, tissue macrophages, Langerhans cells, dendritic cells, T and B cells, natural killer (NK) cells, large granular lymphocytes (LGL), vascular endothelium, smooth muscle, fibroblasts, thymic epithelia, astrocytes, microglia, glioma, keratinocytes,
Cellular Targets: B cells, T cells, monocytes
Receptors: Type I IL-1R (CDw121a), Type II IL-1R (CDw121b)
Bioactivity/Activities: Stimulates T cells, B cells, proliferation/activation of NK cells, fibroblasts, thymocytes, glioblastoma cells, astroglia, microglia
Antigen
References:

1. Fitzgerald K, et al. Eds. 2001. The Cytokine FactsBook. Academic Press San Diego.
2. Bomford R, et al. Eds. 1989. Interleukin-1 inflammation and disease. Elsevier New York.
3. Brazel D, et al. 1991. Biotechnol. Ther. 2:241.
4. Dinarello C. 1996. Blood 87:2095.

GeneID: 3553
Latest Publications: View the latest IL-1beta articles on HighwirePress.com
UniProt: View information about IL-1beta on UniProt.org
Keywords: Purified anti-human IL-1β, H1b-98, Purified, Interleukin-1β, H1, OAF, Catabolin, IFNb-inducing factor(il-1b,il1b) , Human, Immunology, Antibodies
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