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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
COA:
Application References:
1. Valentin H, et al. 1992. Transplantation. 54:97
Human peripheral blood lymphocytes stained with purified 097, followed by anti-mouse Ig FITC
CD52, also known as Cambridge pathology antigen 1 (CAMPATH-1), is a 25-29 kD glycoprotein containing a large N-linked carbohydrate moiety. The actual molecule of CD52 is only 8-9 kD. It is expressed in the male reproductive tract and on virtually all lymphocytes (T and B cells), as well as macrophages/monocytes, eosinophils, and red cells. CD52 is thought to play a role in carrying and orienting carbohydrates. CD52 is a potent target for complement-mediated lysis and antibody-mediated cellular cytotoxicity and has been used as a depletion target for chronic lymphocytic leukemia (CLL)/lymphoma and immunosuppression.
Other Names:
Cambridge pathology antigen 1 (CAMPATH-1), epididymal secretory protein 1
Male reproductive tract (epididymis, seminal vesicle), T cells, B cells, macrophage/monocyte, eosinophil, erythrocytes, malignant lymphocytes
Function:
Thought to play a role in carrying and orienting carbohydrates. Target for complement-mediated lysis and antibody-dependent cellular cytotoxicity, used as a depletion target for chronic lymphocytic leukemia/lymphoma therapy and immunosuppression.
Antigen References:
1. Leukocyte Typing VI. Kishimoto T, et al. (Eds.) Garland Publishing Inc. (1997) 2. Xia MQ, et al. 1991. Eur. J. Immunol. 21:1677. 3. Kirchhoff C, et al. 1993. Mol. Reprod. Dev. 34:8. 4. Xia MQ, et al. 1993. Biochem. J. 293:633.
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This data display is provided for general comparisons between formats. Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors. If you need assistance with selecting the best format contact our expert technical support team.
FITC anti-human CD52
Human peripheral blood lymphocytes stained with 097 FITC
Purified anti-human CD52
Human peripheral blood lymphocytes stained with purified 097, followed by anti-mouse Ig FITC
Alexa Fluor® 647 anti-human CD52
Human peripheral blood lymphocytes stained with 097 Alexa Fluor® 647
