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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
COA:
Application Notes:
Additional reported applications include: immunoprecipitation (1), inhibit the interaction of ICAM-3 and LFA-1(1)
Application References:
1. deFougerolles AR and Springer TA, et al. 1992. J. Exp. Med. 175:185
Human peripheral blood lymphocytes stained with purified CBR-IC3/1, followed by anti-mouse IgG FITC
CD50 is a 120-140 kD type I membrane protein also known as intercellular adhesion molecule 3 (ICAM-3). It is broadly expressed on leukocytes, endothelial cells, and Langerhans cells. CD50 is a member of the Ig superfamily. It provides costimulatory signal for T cells and regulates cell adhesion through interaction with LFA-1 (CD11a/CD18, αL/β2) integrin.
Other Names:
ICAM-3
Structure:
Ig superfamily, type I membrane protein, 130 kD
Distribution:
Thymocytes, T and B cells, monocytes, granulocytes, endothelial cells
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This data display is provided for general comparisons between formats. Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors. If you need assistance with selecting the best format contact our expert technical support team.
Purified anti-human CD50 (ICAM-3)
Human peripheral blood lymphocytes stained with purified CBR-IC3/1, followed by anti-mouse IgG FITC
PE anti-human CD50 (ICAM-3)
Human peripheral blood lymphocytes stained with CBR-IC3/1 PE
Alexa Fluor® 647 anti-human CD50 (ICAM-3)
Human peripheral blood lymphocytes stained with CBR-IC3/1 Alexa Fluor®647
APC anti-human CD50 (ICAM-3)
Human peripheral blood lymphocytes stained with CBR-IC3/1 APC
PerCP/Cy5.5 anti-human CD50 (ICAM-3)
Human peripheral blood lymphocytes stained with CBR-IC3/1 PerCP/Cy5.5
