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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
COA:
HT29 (Human Colon Cancer cell line) cells were stained with CD321 (clone OV-5B8) FITC (filled histogram) or mouse IgG1, κ FITC isotype control (open histogram).
CD321, also known as Junctional Adhesion Molecule A (JAM-A), JAM-1, or F11 Receptor, is a 32-40 kD type I transmembrane glycoprotein which belongs to the immunoglobin suerfamily. It is expressed broadly on leukocytes, platelets, erythrocytes, and epithelial and endothelial cells. CD321 plays a role in cell adhesion, leukocyte migration, and angiogenesis, through its interactions with integrins, such as LFA-1 and αvβ3 integrins.
Other Names:
Junctional Adhesion Molecule A, JAM-A, JAM-1, JCAM, F11 R
Structure:
32-40 kD type I trans-membrane glycoprotein, member of the immunoglobin superfamily
Distribution:
Leukocytes, platelets, erythrocytes, epithelial cells, and endothelial cells
Function:
Cell adhesion, angiogenesis
Ligand Receptor:
Integrins
Antigen References:
1. Woodfin A, et al. 2007. Blood 110:1848. 2. Cera MR, et al. 2009. J. Cell Sci. 122:268. 3. Fraemohs L, et al. 2004. J. Immunol. 173:6259. 4. Wojcikiewicz EP, et al. 2009. Biophys. J. 96:285.
*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/terms). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.
This data display is provided for general comparisons between formats. Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors. If you need assistance with selecting the best format contact our expert technical support team.
Purified anti-human CD321 (F11R)
HT29 (Human Colon Cancer cell line) cells were stained with CD321 (clone OV-5B8) FITC (filled histogram) or mouse IgG1, κ FITC isotype control (open histogram).
FITC anti-human CD321 (F11R)
HT29 (Human Colon Cancer cell line) cells were stained with CD321 (clone OV-5B8) FITC (filled histogram) or mouse IgG1, κ FITC isotype control (open histogram).
