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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
COA:
Application Notes:
Additional reported applications for the relevant formats include: immunoprecipitation, western blot, immunohistochemical staining of frozen or paraffin embedded tissue sections, blocking of NGF binding
Application References:
1. Alonzo H, et al. 1984. Proc. Natl. Acad. Sci. USA 81:6681 2. Cattoretti G, et al. 1993. Blood 81:1726 3. Kamke MR, et al. 2005. Hear Res. 206:89
Human neuroblastoma cell line SK-N-MC stained with ME20.4 FITC
CD271, also known as p75NTR, TNFRSF16, p75(NTR), Gp80-LNGFR, NGFR, is a type I transmembrane protein with a MW of 75 kD, expressed by many cell types including neurons, Schwann cells, mesenchymal stem/stromal cells, follicular dendritic cells and melanocytes. The extracellular portion contains four TNFR-Cys repeats that form the binding domain for its ligands, (NGF, BDNF, NTF3 and NTF4). The intracellular portion of CD271 contains a death domain, which interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9, to promote cell apoptosis, and to regulate cell differentiation and neurogenesis.
Type I transmembranal protein with a MW of 75 kD. The extracellular portion contains four TNFR-Cys repeats that form the NGF binding domain; the intracellular portion contains a death domain.
Distribution:
Expressed by many cell types including neurons, Schwann cells, mesenchymal stem/stromal cells, follicular dendritic cells, melanocytes
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This data display is provided for general comparisons between formats. Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors. If you need assistance with selecting the best format contact our expert technical support team.
Purified anti-human CD271 (NGFR)
Human neuroblastoma cell line SK-N-MC stained with ME20.4 FITC
FITC anti-human CD271 (NGFR)
Human neuroblastoma cell line SK-N-MC stained with ME20.4 FITC
PE anti-human CD271 (NGFR)
Human neuroblastoma cell line SK-N-MC stained with ME20.4 PE
APC anti-human CD271 (NGFR)
Human neuroblastoma cell line, SK-N-MC, stained with ME20.4 APC
