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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
COA:
Application Notes:
Additional reported applications include: immunoprecipitation, Wstern blot, immunohistochemical staining of frozen tissue sections and ELISA
Application References:
1.Peters KG, et al. 1998. Br. J. Cancer. 77:51. 2.Wong AL, et al. 1997. Circ. Res. 81:567. 3.Lin P, et al. 1998. P. Natl. Acad. Sci. USA 95:8829.
Human endothelial cells (HUVEC) stained with purified AB33, followed by biotinylated anti-mouse IgG and Sav-PE
CD202b is a 145 kD type I transmembrane protein, also known as Tie2 or TEK. It is a member of the receptor tyrosine kinase (RTK) family of proteins and is expressed by endothelial cells and their progenitors, quiescent hematopoietic stem cells (HSCs), and a subpopulation of monocytes. Angiopoietin-1 (Ang-1) is an activator of CD202b to promote, maintain, and stabilize mature vessels and to maintain HSCs in quiescent state. Ang-2 is another ligand of CD202b, which is involved in postnatal angiogenesis and in antagonizing the effects of Ang-1. Tie2 binds to Ang-4 as well.
Other Names:
Tie2, TEK
Structure:
145 kD type I transmembrane protein, receptor tyrosine kinase (RTK) family
Distribution:
Endothelial cells, subsets of hematopoietic stem cells and and a subset of monocytes
Function:
Angiogenesis, hemotopoiesis, monocytes chemotaxis
Ligand Receptor:
Angiopoietin-1 (Ang-1), Ang-2, and Ang-4
Antigen References:
1.De Palma M, et al. 2005. Cancer Cell. 8:211 2.Shaw JP, et al. 2004. Blood Cells Mol. Dis. 32:168 3. Hsu HC, et al. 2000. Blood. 96:3757 4. Arai F, et al. 2004. Cell. 118:149
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This data display is provided for general comparisons between formats. Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors. If you need assistance with selecting the best format contact our expert technical support team.
Purified anti-human CD202b (Tie2/Tek)
Human endothelial cells (HUVEC) stained with purified AB33, followed by biotinylated anti-mouse IgG and Sav-PE
Biotin anti-human CD202b (Tie2/Tek)
Human endothelial cell line, HUVEC, stained with biotinylated 33.1, followed by Sav-PE
PE anti-human CD202b (Tie2/Tek)
Human endothelial cell line, HUVEC, stained with 33.1 PE
Alexa Fluor® 488 anti-human CD202b (Tie2/Tek)
Human endothelial cell line, HUVEC, stained with 33.1 Alexa Fluor® 488
Alexa Fluor® 647 anti-human CD202b (Tie2/Tek)
Human endothelial cell line, HUVEC, stained with 33.1 Alexa Fluor® 647
