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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
COA:
HUVEC cells were stained with CD201 (clone RCR-401) PE (filled histogram) or rat IgG1, κ PE isotype control (open histogram).
Endothelial protein C receptor (EPCR), also known as CD201, is a 46 kD N-glycosylated type I transmembrane protein primarily expressed on the endothelial cells of arteries and veins in heart and lung. It is also expressed at high levels on a subset of hematopoietic stem cells and a subset of dendritic cells. CD201 functions as a primary receptor for protein C activation, which results in inhibition of both intrinsic and extrinsic coagulation pathways. It also plays an important role in many pathophysiologic processes, such as inflammation responses to infection, trauma, hematopoiesis, and autoimmune response. Deletion of the CD201 gene in knock-out mice leads to embryonic lethality before embryonic day 10, indicating that CD201 expression is critical for embryo development. In humans, mutations of CD201 have been associated with venous thromboembolism and myocardial infarction as well as with late fetal loss during pregnancy.
Other Names:
Endothelial protein C receptor, protein C receptor, PROCR, activated protein C receptor, APC receptor
Structure:
46 kD of N-glycosylated type I transmembrane protein
Distribution:
Endothelial cells, subset of hematopoietic stem cells, subset of dendritic cells
Function:
Inhibits blood coagulation, inflammation, and hematopoiesis
Ligand Receptor:
Protease C
Interaction:
Activated receptor1 (Par-1)
Antigen References:
1. Kerschen E, et al. 2010. J. Clin. Invest. 120:3167. 2. Iwasaki H, et al. 2010. Blood 116:544. 3. Balazs AB, et al. 2006. Blood 107:2317.
Purified anti-human CD201 (EPCR), RCR-401, Purified, Endothelial protein C receptor, protein C receptor, PROCR, activated protein C receptor, APC receptor, Human, Immunology, Antibodies
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This data display is provided for general comparisons between formats. Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors. If you need assistance with selecting the best format contact our expert technical support team.
PE anti-human CD201 (EPCR)
HUVEC cells were stained with CD201 (clone RCR-401) PE (filled histogram) or rat IgG1, κ PE isotype control (open histogram).
Purified anti-human CD201 (EPCR)
HUVEC cells were stained with CD201 (clone RCR-401) PE (filled histogram) or rat IgG1, κ PE isotype control (open histogram).
APC anti-human CD201 (EPCR)
HUVEC cells were stained with CD201 (clone RCR-401) APC (filled histogram) or rat IgG1, κ APC isotype control (open histogram).
