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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
COA:
Human peripheral blood lymphocytes were stained with ADAM10 (SHM14) PE (filled histogram) or mouse IgG1, κ PE isotype control (open histogram).
CD156c, also known as A Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10), is a 748 amino acid type I membrane glycoprotein ubiquitously expressed on most of the cell types. It consists of multiple functional domains, including a N-terminal prodomain, catalytic domain, cysteine-rich domain, transmembranous domain, and cytoplasmic domain. It is secreted as a precursor protein and becomes as the activate/mature form through removing the ADAM10 prodomain by proprotein convertase 7 and furin. ADAM10 functions as metalloproteinase to cleave several molecules including Notch, pro-TNF-α, amyloid precursor protein, myelin basic protein, and type IV collagen. It mediates the release of several cell adhesion molecules such as vascular endothelial cadherin or L-selectin to regulate endothelial permeability and leukocyte transmigration. Dysregulation of ADAM activity may contribute to the pathogenesis of vascular diseases.
Other Names:
MADM, KUZ
Structure:
Consist of signal sequence, a N-terminal prodomain followed by a catalytic proteinase domain containing a zinc-binding motif, a disintegrin, cysteine-rich transmembrane, and a cytoplasmatic domain
Distribution:
Ubiquitously expressed on most of the cell types
Function:
Acts as an efficient α-secretase
Interaction:
Proteolysis the amyloid precursor protein (APP)
Antigen References:
1. Edwards DR, et al. 2008. Mol. Aspects Med. 29:258. 2. Anders A, et al. 2001. FASEB J. 15:1837. 3. Endres K, et al. 2010. FEBS J. 277:1585. 4. Mochizuki S, et al. 2007. Cancer Sci. 98:621.
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This data display is provided for general comparisons between formats. Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors. If you need assistance with selecting the best format contact our expert technical support team.
Purified anti-human CD156c (ADAM10)
Human peripheral blood lymphocytes were stained with ADAM10 (SHM14) PE (filled histogram) or mouse IgG1, κ PE isotype control (open histogram).
PE anti-human CD156c (ADAM10)
Human peripheral blood lymphocytes were stained with ADAM10 (SHM14) PE (filled histogram) or mouse IgG1, κ PE isotype control (open histogram).
