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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
COA:
Human cervical cancer cell line, Hela, stained with purified SHM-57 conjugated with PE
CD146 is a 118 kD integral transmembrane glycoprotein, also known as MUC18, S-Endo, MCAM, and Mel-CAM (melanoma cell adhesion molecule). It belongs to the immunoglobulin superfamily. CD146 is expressed on melanoma cells, epithelial cells, endothelial cells, fibroblasts, activated T cells, multipotent mesenchymal stromal cells, and activated keratinocytes. CD146 mediates heterophilic cell adhesion and regulates monocyte transendothelial migration. The ligand of CD146 remains to be identified.
1. Pickl WF, et al. 1997. J. Immunol. 158:2107 2. Weninger W, et al. 2000. J. Invest. Dermatol. 115:219 3. Sorrentino A, et al. 2008. Exp. Hematol. 36:1035 4. Bardin N, et al. 2009. Arterioscler. Thromb. Vasc. Biol. 29:746
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This data display is provided for general comparisons between formats. Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors. If you need assistance with selecting the best format contact our expert technical support team.
Purified anti-human CD146 (MUC18, Mel-CAM)
Human cervical cancer cell line, Hela, stained with purified SHM-57 conjugated with PE
PE anti-human CD146 (MUC18, Mel-CAM)
Human cervical cancer cell line, Hela, stained with SHM-57 PE
Human cervical cancer cell line, Hela, stained with SHM-57 Alexa Fluor® 488
PE/Cy7 anti-human CD146 (MUC18, Mel-CAM)
Human cervical cancer cell line, Hela, stained with SHM-57 PE/Cy7
APC anti-human CD146 (MUC18, Mel-CAM)
Human cervical cancer cell line, Hela, stained with CD146 (clone SHM-57) APC (filled histogram) or mouse IgG2a, κ APC isotype control (open histogram).
