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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ≤ 2.0 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
COA:
Human peripheral blood monocytes stained with M80 PE
LPS-stimulated (overnight) human peripheral blood mononuclear cells stained with M80 PE (gated on CD14+ cells)
CD141 is a 75 kD, single chain, type I membrane glycoprotein also known as thrombomodulin, TM, THRM, THBD, and fetomodulin. CD141 is an important cofactor in the protein C anticoagulant system. After binding to its ligand thrombin, CD141 activates protein C, which degrades clotting factors Va and VIIIa, and as a consequence the amount of thrombin is reduced. CD141 is expressed on macrophages, monocytes, a subpopulation of myeloid dendritic cells, vascular endothelial cells, and keratinocytes. Besides anti-coagulation function, CD141 is also involved in embryonic and atherosclerotic plaque development.
After thrombin binding, CD141 activates protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated.
Ligand Receptor:
Thrombin
Interaction:
Protein C, Thrombin-activatable fibrinolysis inhibitor (TAFI), Platelet factor 4 (PF4)
Antigen References:
1. Suzuki K, et al. 1987. EMBO J. 6:1891. 2. Esmon CT, et al. 1989. J. Biol. Chem. 264:4743. 3. Delvaeye M, et al. 2009. N. Engl. J. Med. 361:345. 4. Shi CS, et al. 2008. Blood 112:3661. 5. Chen LC, et al. 2009. J. Infect. 58:368.
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This data display is provided for general comparisons between formats. Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors. If you need assistance with selecting the best format contact our expert technical support team.
Purified anti-human CD141 (Thrombomodulin)
Human peripheral blood monocytes stained with M80 PE
LPS-stimulated (overnight) human peripheral blood mononuclear cells stained with M80 PE (gated on CD14+ cells)
PE anti-human CD141 (Thrombomodulin)
Human peripheral blood monocytes stained with M80 PE
LPS-stimulated (overnight) human peripheral blood mononuclear cells stained with M80 PE (gated on CD14+ cells)
APC anti-human CD141 (Thrombomodulin)
Human peripheral blood monocytes were stimulated with LPS (overnight) and then stained with CD141 (clone M80) APC (filled histogram) or mouse IgG1, κ APC isotype control (open histogram). Data shown was gated on the CD14+ cell population.
Biotin anti-human CD141 (Thrombomodulin)
Human peripheral blood monocytes were stained with biotinylated CD141 (clone M80, filled histogram) or mouse IgG1, κ (open histogram) isotype control, followed by Sav-PE.
PE/Cy7 anti-human CD141 (Thrombomodulin)
LPS-stimulated (overnight) human peripheral blood monocytes were stained with CD141 (clone M80) PE/Cy7 (filled histogram) or mouse IgG1, κ PE/Cy7 isotype control (open histogram). Data shown was gated on the CD14+ cell population.
PerCP/Cy5.5 anti-human CD141 (Thrombomodulin)
LPS-stimulated (overnight) human peripheral blood monocytes were stained with CD141 (clone M80) PerCP/Cy5.5 (filled histogram) or mouse IgG1, κ PerCP/Cy5.5 isotype control (open histogram). Data shown was gated on the CD14+ cell population.
