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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ≤0.125 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
COA:
Application References:
1. Itano M, et al. 1996. J. Exp. Med. 178:389 2. Kondo M, et al. 1993. Science 262:1874
Description:
CD132 is a 64-70 kD type I transmembrane glycoprotein of the Ig superfamily, also known as common γ chain (γc), or IL-2 receptor γ subunit. It is expressed broadly on T- and B-lymphocytes, NK cells, monocytes, and granulocytes. CD132 is an essential component of cytokine receptors for IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21. Ligand binding induces tyrosine phosphorylation and initiates signaling through a JAK/STAT pathway. CD132 mutation results in X-linked severe combined immune deficiency (XSCID).
Other Names:
Common γ chain, γc, IL-2 receptor γ subunit
Structure:
Type I transmembrane glycoprotein, Ig superfamily 64-70 kD
Distribution:
T, B, NK, monocytes, granulocytes
Ligand Receptor:
Component of cytokine receptors for IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21
Antigen References:
1. Zola H, et al. eds. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers. Wiely-Liss A John Wiley & Sons Inc, Publication 2. Nakarai T, et al. 1994. J. Exp. Med. 180:241 3. Kawahara A, et al. 1995. Proc. Natl. Acad. Sci. USA. 92:8724 4. Habib T, et al. 2002. Biochemistry. 41:8725 5. Matthews DJ, et al. 1995. Blood 85:38
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