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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µl volume or 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
COA:
Application Notes:
Additional reported applications (for the relevant formats) include: immunoprecipitation2, Western blotting1 and immunohistochemical staining of acetone-fixed frozen tissue sections.
Application References:
1. Stomski FC, et al. 1998. J. Biol. Chem. 273:1192. (WB) 2. McClure B, et al. 2001. Blood 98:3165. (IP) 3. Guthridge MA, et al. 2004. Blood 103:820.
Human peripheral blood monocytes stained
with 4H1 FITC
CD116 is a 70-85 kD α chain of the GM-CSF receptor. It combines with CDw131 β chain to form the high affinity GM-CSF receptor. A soluble form of CD116, which binds GM-CSF with a relatively low affinity, has been identified. In addition, an alternatively spliced form of CD116 with an altered cytoplasmic tail has been described. CD116 is expressed on various myeloid cells including monocytes, macrophages, neutrophils, eosinophils, dendritic cells and their precursors, fibroblasts, and endothelial cells. CD116 is expressed on myeloid leukemias, osteogenic sarcoma cell lines, osteoblast-like cells and breast and lung carcinoma cell lines.
Other Names:
GM-CSFRα chain
Structure:
Ig superfamily, type I transmembrane glycoprotein, associates with CDw131, 70-85 kD
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This data display is provided for general comparisons between formats. Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors. If you need assistance with selecting the best format contact our expert technical support team.
Biotin anti-human CD116
Human peripheral blood monocytes stained
with 4H1 FITC
FITC anti-human CD116
Human peripheral blood monocytes stained
with 4H1 FITC
PE anti-human CD116
Human peripheral blood monocytes stained
with 4H1 FITC
Purified anti-human CD116
Human peripheral blood monocytes stained
with 4H1 FITC
