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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
B7-H2, a member of the B7 family and the immunoglobulin superfamily, is a 40 kD protein also known as B7RP-1, B7h, B7-H2, GL50 and ICOS Ligand. Human B7-H2 is expressed by activated monocytes/macrophages and dendritic cells. B7-H2 binds to a CD28-like receptor, inducible costimulator molecule (ICOS, AILIM, CRP-1), which is expressed by activated T cells. The interaction of ICOS with B7-H2 plays an important role in the T cell costimulation pathway.
CD275, ICOSL, B7H2, ICOS-L, B7RP-1, B7-RP1
Ig superfamily, B7 family, 40 kD
B cells and dendritic cells
Binds ICOS on antigen-activated T cells and mediates proliferation and cytokine production
1. Wang S, et al. 2002. J. Biol. Chem. 96:2808. 2. Wong SC, et al. 2003. Blood 102:1831.
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PE anti-human CD275 (B7-H2, ICOSL)
Human monocyte-derived dendritic cells stained with 2D3 PE
Purified anti-human CD275 (B7-H2, ICOSL)
Human monocyte-derived dendritic cells stained with purified 2D3, then detected with biotinylated anti-mouse IgGs and Sav-PE
Biotin anti-human CD275 (B7-H2, ICOSL)
Human monocyte-derived dendritic cells stained with biotinylated 2D3,followed by Sav-PE