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Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 μl per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.
COA:
HeLa cell extracts were resolved by electrophoresis, transferred to nitrocellulose, and probed with polyclonal anti-FGFR1 antibody (clone Poly6162). Proteins were visualized using a donkey anti-rabbit secondary conjugated to HRP and chemiluminescence detection.
FGFR1 (fibroblast growth factor receptor 1) is a member of the fibroblast growth factor receptor family containing an Ig-like domain and a tyrosine kinase domain. This receptor has multiple isoforms and is a Type I membrane protein. FGFR1 is a widely expressed membrane receptor, with distinct isoforms expressed in specific tissues. FGFR1 binds fibroblast growth factor and induces mitogenesis and cellular differentiation. Defects in FGFR1 result in Pfeiffer syndrome associated with craniosynostosis. This receptor can be upregulated by TGF-β1 in lung fibroblasts and by platelet derived growth factor-BB in fibroblasts. FGFR1 can be modified by phosphorylation and can bind basic/acidic fibroblast factor depending on the receptor isoform. FGFR1 has been shown to interact with N-cadherin and NCAM. ThePoly6162 antibody recognizes human FGFR1 (multiple isoforms) and has been shown to be useful for Western blotting.
Type I membrane protein. Widely expressed membrane receptor, distinct isoforms expressed in specific tissues
Function:
Interacts with fibroblast growth factor to induce mitogenesis and differentiation. Defects cause Pfeiffer syndrome associated with craniosynostosis
Regulation:
Upregulated by TGF-β1 in lung fibroblasts, by platelet derived growth factor-BB in fibroblasts
Modification:
Phosphorylation
Interaction:
Binds basic/acidic fibroblast factor depending on isoform. Interacts with N-cadherin, NCAM
Antigen References:
1. Johnson D, et al. 1990. Mol. Cell. Biol. 10:4728. 2. Muenke M, et al. 1994. Nat. Genetics 8:269. 3. Groth C, et al. 2002. Int. J. Dev. Biol. 46:393.
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Purified anti-FGFR1
HeLa cell extracts were resolved by electrophoresis, transferred to nitrocellulose, and probed with polyclonal anti-FGFR1 antibody (clone Poly6162). Proteins were visualized using a donkey anti-rabbit secondary conjugated to HRP and chemiluminescence detection.
