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Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 µl per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.
COA:
Recombinant human C-reactive protein (20 ng per lane) was resolved by electrophoresis, transferred to nitrocellulose, and probed with rabbit polyclonal antibody against CRP. Proteins were visualized using a donkey anti-rabbit secondary conjugated to HRP and a chemiluminescence detection system.
CRP (C-reactive protein) is a member of the pentaxin family. CRP exists as a homopentamer in a discoid arrangement (noncovalently attached). Individual subunits are approximately 24 kD, the molecular weight of the entire molecule is approximately 120 kD CRP is secreted and can be found in plasma. This protein promotes agglutination, phagocytosis, and complement fixation through Ca2+-dependent binding to phosphorylcholine. CRP is thought to scavenge nuclear material released from damaged circulating cells. CRP is the major protein involved in acute phase response to pathogens; both CRP and degradation products of CRP act as anti-inflammatory agents. CRP has been shown to interact with both DNA and histones. The Poly6208 antibody recognizes human CRP and has been shown to be useful for Western blotting.
Other Names:
C-reactive protein, pentraxin-related
Structure:
Member of the pentaxin family. Exists as a homopentamer in a discoid arrangement (noncovalently attached). Individual subunits are approximately 24 kD, the molecular weight of the entire molecule is approximately 120 kD
Distribution:
Secreted, found in plasma
Function:
Promotes agglutination, phagocytosis, and complement fixation through Ca2+-dependent binding to phosphorylcholine. Thought to scavenge nuclear material released from damaged circulating cells. Major protein involved in acute phase response to p
Regulation:
Can be degraded. Both CRP and degradation products act as anti-inflammatory agents.
Interaction:
Interacts with DNA and histones
Antigen References:
1. Whitehead AS, et al. 1983. Science 221:69. 2. Tucci A, et al. 1983. J. Immunol. 131:2416. 3. Szalai AJ. 2002. Vascul. Pharmacol. 39:105 (review). 4. Chang MK, et al. 2002. P. Natl. Acad. Sci. USA 99:13043.
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This data display is provided for general comparisons between formats. Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors. If you need assistance with selecting the best format contact our expert technical support team.
Purified anti-CRP (C-reactive protein)
Recombinant human C-reactive protein (20 ng per lane) was resolved by electrophoresis, transferred to nitrocellulose, and probed with rabbit polyclonal antibody against CRP. Proteins were visualized using a donkey anti-rabbit secondary conjugated to HRP and a chemiluminescence detection system.
