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Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 μl per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.
Hela cell extract was resolved by electrophoresis, transferred to nitrocellulose and probed with rabbit anti-centrin 2 antibody. Proteins were visualized using a donkey anti-rabbit secondary conjugated to HRP and a chemiluminescence detection system.
Centrin 2, also known as caltractin, EF-hand protein 2, and 20 kD calcium-binding protein, is a calcium-binding protein that contains 4 EF-hand domains. Centrin 2 is highly expressed in the retina and testis, also expressed in liver, skeletal muscle and cardiac muscle. The centrin-2 protein plays a critical function in normal cell division,and is known to associate with the centrosomes, mitotic spindle poles, and basal bodies. Centrin 2 has a fundamental role in the structure and function of the microtubule-organizing center and has been shown to associate with the RAD23B, SFI1, and Xeroderma pigmentosum group C complementing proteins. The Poly6288 antibody recognizes human centrin 2 and has been shown to be useful for Western blotting.
Other Names:
EF-hand protein 2, 20 kD calcium-binding protein, Caltractin
Structure:
Contains 4 EF-hand domains, calcium binding protein, approximately 20-21 kD
Distribution:
Highly expressed in the retina and testis, also expressed in liver, skeletal muscle and cardiac muscle
Function:
Plays a critical function in normal cell division, associates with the centrosomes, mitotic spindle poles, and basal bodies. Has a fundamental role in the structure and function of the microtubule-organizing center.
Interaction:
RAD23B, SFI1, Xeroderma pigmentosum group C complementing protein
Antigen References:
1. Lee VD and Huang B. 1993. Proc. Natl. Acad. Sci. 90:11039. 2. Tanaka T, et al. 1994. Genomics 24:609.
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This data display is provided for general comparisons between formats. Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors. If you need assistance with selecting the best format contact our expert technical support team.
Purified anti-Centrin 2 (Caltractin)
Hela cell extract was resolved by electrophoresis, transferred to nitrocellulose and probed with rabbit anti-centrin 2 antibody. Proteins were visualized using a donkey anti-rabbit secondary conjugated to HRP and a chemiluminescence detection system.
