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Purified anti-Caspase-2L Antibody
Purified anti-Caspase-2L Antibody
634001 125 µl (5 Western blots) ¥19,000     
634002 500 µl (20 Western blots) ¥45,000     
Product Details
Clone: Poly6340
Isotype: Rabbit Polyclonal
Reactivity: Human, Mouse, Rat
Immunogen: Peptide mapping to the carboxy terminal of human caspase-2L.
Formulation: This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% gelatin.
Preparation: This antibody was purified by affinity chromatography.
Storage & Handling: The antibody solution should be stored undiluted at 4°C. DO NOT FREEZE.
Application:

WB - Quality tested
IP - Reported in the literature
Recommended Usage:

Each lot of this antibody is quality control tested by Western blotting.  Western blotting suggested working dilution(s): Use 25µl per 5 ml antibody dilution buffer for each mini-gel.  It is recommended that the reagent be titrated for optimal performance for each application.
COA:
Enter Lot#:   
 Western blot analysis of extracts
Western blot analysis of extracts from Hela cells, using anti-caspase-2L, Poly6340.


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Description:

Caspase 2 (Nedd-2/ICH-1) is a member of the peptidase family C14 that contains a CARD domain. This caspase has been reported to have two isoforms.The larger protein, Caspase-2L(ICH-1L) possesses proapoptotic activities , whereas Caspase-2S (ICH-1S) is able to inhibit apoptosis.When cells are induced to undergo apoptosis, endogenous Caspase 2 is probably activated early in the apoptotic process by cleaves into three fragments of 33 and 14 kD, and then these are further processed into 18 and 12 kD active subunits. The Poly6340 antibody has been shown to be useful for western blotting, immunoprecipitation, and immunohistochemistry of human, mouse, and rat caspase-2L p12 subunit and precursor (also designated Ich-1L).
Other Names: ICH-1L, CASP2L
Structure: Belongs to the peptidase C14 family, contains 1 CARD domain, heterodimer of a p18 subunit and a p12 subunit, and 2 alternative splicing isoforms of ICH-1L and ICH-1S.
Distribution: Cytoplasm, mitochondrial
Bioactivity/Activities: Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.
Antigen
References:

1. Wang L, et al. 1994. Cell 78:739
GeneID: 8795
Latest Publications: View the latest Caspase-2L articles on HighwirePress.com
UniProt: View information about Caspase-2L on UniProt.org
Keywords: Purified anti-Caspase-2L, Poly6340, Purified, ICH-1L, CASP2L , Human, Mouse, Rat, Immunology, Antibodies
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  • Purified anti-Caspase-2L
    Western blot analysis of extracts

    Western blot analysis of extracts from Hela cells, using anti-caspase-2L, Poly6340.

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