Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 µl per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.
Description:
14-3-3epsilon is a 29 kD protein that belongs to the family of 14-3-3 proteins.This family of proteins mediates signal transduction and cell cycle progression by binding to phosphoserine and phosphothreonine motifs on a large number of target molecules.14-3-3 proteins activate tyrosine and tryptophan hydroxylases and protein kinase C.There are eight known isoforms of 14-3-3: alpha, beta, gamma, delta, epsilon, zeta, eta, and theta.The Poly6379 antibody has been shown to be useful for western blotting of human 14-3-3 epsilon protein.
Other Names:
14-3-3E, YWHAE < YWHAE>
Structure:
14-3-3 protein superfamily, homodimer, 29 kD
Distribution:
Cytoplasm
Function:
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif.
1. Jin D.-Y., et al. 1996. Nature 382:308. 2. Conklin D.S., et al. 1995. Proc. Natl. Acad. Sci. U.S.A. 92:7892. 3. Zannis-Hadjopoulos M., et al. 2008. Trends Biochem. Sci. 33:44.
*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering/). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.
