p53 p53 CHK2 CHK2 Bim PARP DAXX NFKB CytoC BCL BAX Caspase 9 Caspase 8 Caspase 8 Caspase 8 Caspase 8 caspase 3 IkB AKT PKC p90 FasL Fas TNF-a TNF-R TWEAK CD266 CD253 CD261 BCL-2 Cellular Apoptosis Pathway