TNF-a TNF-R Src Cbl 14-3-3 14-3-3 14-3-3 14-3-3 14-3-3 14-3-3 14-3-3 14-3-3 14-3-3 14-3-3 14-3-3 14-3-3 14-3-3 14-3-3 c-Jun c-Fos Tubulin Rsk GSK3B JNK AKT Erk MEK PKC Raf TSC VEGF Phosphotyrosine Phosphotyrosine Phosphotyrosine Phosphotyrosine Phosphotyrosine Phosphotyrosine Phosphotyrosine Phosphotyrosine DAG DAF 14-3-3 Induced Intracellular Signaling