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The antibody was purified by affinity chromatography, and conjugated with PerCP/Cy5.5 under optimal conditions. The solution is free of unconjugated PerCP/Cy5.5 and unconjugated antibody.
Storage & Handling:
The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is 5 µl per million cells or 5 µl per 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
* PerCP/Cy5.5 has a maximum absorption of 482 nm and a maximum emission of 690 nm.
COA:
Cy3, Cy5, Cy5.5 and Cy7 are subject to proprietary rights of GE Healthcare Bio-Sciences Corp. and Carnegie Mellon University and made and sold under license from GE Healthcare Bio-Sciences Corp. Sale of this product is licensed for research use only.
Application References:
1. Poggi A, et al. 1995. Eur. J. Immunol. 25:369
Human peripheral blood lymphocytes stained with NKTA255 PerCP/Cy5.5 and anti-CD19 (HIB19) APC
CD305, also known as LAIR-1 (leukocyte-associated Ig-like receptor-1), is a 40 kD type I transmembrane glycoprotein. LAIR-1 and LAIR-2 are the only members of the LAIR family in the Ig superfamily. LAIR-1 is an inhibitory molecule characterized by ITIMs in the cytoplasmic domain and collagen ligands. CD305 is expressed on NK cells, T cells, B cells, monocytes, dendritic cells, eosinophils, basophils and mast cells. LAIR-1 functions in the inhibition of cell cytotoxicity, cell activation, proliferation and differentiation.
Other Names:
LAIR-1 (Leukocyte-associated Ig-like receptor 1)
Structure:
40 kD type I transmembrane protein, cytoplasmic domain contains ITIM motifs, Ig superfamily
Distribution:
NK cells, T cell, B cells, monocytes, dendritic cells, eosinophils, basophils and mast cells
Function:
Inhibition of cell cytotoxicity, cell activation, proliferation and differentiation
Ligand Receptor:
collagens
Antigen References:
1. Meyaard L, et al. 2008. J. Leukoc. Biol. 83:799 2. Lebbink RJ, et al. 2006. J. Exp. Med. 203:1419
*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/terms). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.
This data display is provided for general comparisons between formats. Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors. If you need assistance with selecting the best format contact our expert technical support team.
Alexa Fluor® 647 anti-human CD305 (LAIR1)
CD3+ human peripheral blood lymphocytes stained with NKTA255 Alexa Fluor® 647 and CD4 (RPA-T4) PE
PerCP/Cy5.5 anti-human CD305 (LAIR1)
Human peripheral blood lymphocytes stained with NKTA255 PerCP/Cy5.5 and anti-CD19 (HIB19) APC
