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The antibody was purified by affinity chromatography, and conjugated with PE/Cy5 under optimal conditions. The solution is free of unconjugated PE/Cy5 and unconjugated antibody.
Storage & Handling:
The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. Test size products are transitioning from 20 µl to 5 µl per test. Please check your vial or your CoA to find the suggested use of this reagent per million cells in 100 µl staining volume or per 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. Read more at www.biolegend.com/testsize regarding the test size change.
COA:
Application Notes:
Additional reported applications (for the relevant formats) include: The 8F1/CXCR1 antibody is useful for immunofluorescent staining and flow cytometric analysis of CXCR1 expression.
Cy3, Cy5, Cy5.5 and Cy7 are subject to proprietary rights of GE Healthcare Bio-Sciences Corp. and Carnegie Mellon University and made and sold under license from GE Healthcare Bio-Sciences Corp. Sale of this product is licensed for research use only.
Human peripheral blood granulocytes stained with 8F1/CXCR1 PE/Cy5
CXCR1 is a 67-70 kD seven-transmembrane protein, also known as IL-8 receptor A (IL-8RA), CD181, and CDw128a. It is a CXC chemokine receptor belongs to G protein-coupled receptor (CPCR) family. CXCR1 is expressed as homodimer or heterodimer with CXCR2 and found on granulocytes, NK cells, subset of T lymphocytes, mast cells, monocytes, endothelial cells, megakarocytes, and oligodendrocytes. The expression level of CXCR1 on monocytes is lower that of CXCR2. CXCR1 mediates nurophil activation and chemotaxis, megakaryocytic proliferation, and angiogenesis via binding its ligands including IL-8(CXCL8), NAP-2(CXCL7), GCP-2(CXCL6), and GRO-α(CXCL1).
Other Names:
CD181, CXCR1, CDw128, CD128a, IL-8RA, Type I IL-8 receptor
Structure:
Seven transmembrane spanning, G protein-coupled receptor (CPCR), 67-70 kD, homodier or teterodimer with CXCR2
Distribution:
Granulocytes, NK cells, subset of T cells, monocytes, endothelial cells, oligodendrocytes
1. Chuntharapai A, et al. 1994. J. Immunol. 153:5682. 2. Wilson S, et al. 2005. J. Biol. Chem. 280:28663. 3. Emadi S, et al. 2005. Blood 105:464. 4. Omari KM, et al. 2005. Brain 128:1003. 5. Juremalm M, G. Nilsson. 2005. Chem. Immunol. Allergy. 87:130. 6. Wolf M, et al. 1998. Eur. J. Immunol. 28:164
*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/terms). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.
This data display is provided for general comparisons between formats. Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors. If you need assistance with selecting the best format contact our expert technical support team.
Purified anti-human CD181 (CXCR1)
Human peripheral blood granulocytes stained with purified 8F1/CXCR1, followed by anti-mouse IgG FITC
FITC anti-human CD181 (CXCR1)
Human peripheral blood granulocytes stained with 8F1/CXCR1 FITC
PE anti-human CD181 (CXCR1)
Human peripheral blood granulocytes stained with 8F1 PE
PE/Cy5 anti-human CD181 (CXCR1)
Human peripheral blood granulocytes stained with 8F1/CXCR1 PE/Cy5
APC anti-human CD181 (CXCR1)
Human peripheral blood granulocytes stained with 8F1/CXCR1 APC
Alexa Fluor® 488 anti-human CD181 (CXCR1)
Human peripheral blood granulocytes stained with 8F1/CXCR1 Alexa Fluor® 488
