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The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
Concentration:
0.2 mg/ml
Storage & Handling:
The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
COA:
Application References:
1. Lefrancois L, et al. 1990. Cell. 66:33 2. Sperling AI, et al. 1992. J. Immunol. 149(10):3200 3. Pereira P, et al. 1997. Proc. Natl. Acad. Sci. USA. 94:5761
C57BL/6 lymph node cells stained with GL2 PE and CD3e (145-2C11) APC
C57BL/6 lymph node cells stained with Armenian Hamster IgG (HTK888) PE isotype control and CD3e (145-2C11) APC
Lymphocytes expressing γ/δ antigen receptors constitute a minor population in lymphoid tissue, but a major population within epidermal, gastraintestine, and vaginouterine epithelia. Gamma/Delta T cells are involved in immunological surveillance of epithelia separating the external environment from the internal milieu. The GL2 antibody reacts with Vδ4 T-cell receptor (TCR) bearing T cells, which are the predominant γ/δ T cells in intestinal epithelium (γ/δ IEL). Gamma/delta T cells has been found in mammary glad as well. The frequency of Vδ4 TCR-bearing cells varies among inbred strains of mice.
Other Names:
T cell receptor Vδ4
Structure:
Form heterodimer with TCR gamma chain, associate with CD3 complex.
Distribution:
Expressed on Vδ4 T-cell receptor (TCR) bearing T cells, which are predominant γ/δ T cells in intestinal epithelium.
Function:
Involved in immunological surveillance of epithelia separating the external environment from internal milieu.
Ligand Receptor:
Antigen peptide bound to MHC molecule
Antigen References:
1. Reardon C et al. 1990. J. Exp. Med. 172:1263 2. Goodman T et al. 1989. J. Exp. Med. 170:1569
*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/terms). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.
This data display is provided for general comparisons between formats. Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors. If you need assistance with selecting the best format contact our expert technical support team.
PE anti-mouse TCR Vδ4
C57BL/6 lymph node cells stained with GL2 PE and CD3e (145-2C11) APC
C57BL/6 lymph node cells stained with Armenian Hamster IgG (HTK888) PE isotype control and CD3e (145-2C11) APC
FITC anti-mouse TCR Vδ4
C57BL/6 lymph node cells stained with GL2 FITC and CD3e (145-2C11) APC
C57BL/6 lymph node cells stained with Armenian Hamster IgG (HTK888) FITC isotype control and CD3e (145-2C11) APC
Purified anti-mouse TCR Vδ4
C57BL/6 lymph node cells stained with GL2 PE and CD3e (145-2C11) APC
C57BL/6 lymph node cells stained with Armenian Hamster IgG (HTK888) PE isotype control and CD3e (145-2C11) APC
