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The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
Concentration:
0.2 mg/ml
Storage & Handling:
The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ≤0.015 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
COA:
Application References:
1. Lodoen M, et al. 2003. J. Exp. Med. 197:1245 2. Carayannopoulos LN, et al. 2002. Eur J. Immunol.32 (3):597
RAE-1δ transfected cells stained with Charlotte d1.23 PE
RAE-1δ is one of the five RAE-1 family, GPI-linked membrane protein consisting of alpha, beta, gamma, delta, and epsilon. They are strong homology within the family, related by 92%-95% sequence identity. They are distantly related to MHC class I proteins. RAE-1 proteins are abundantly expressed in fetal tissues, but not in normal adult tissue. They are constitutively expressed on some tumors and can be induced by retinoid acid. Its ligand NKG2D is found on NK cells, many transformed cell lines, and LPS-stimulated peritoneal macrophages. The interaction of NKG2D with RAE-1 transmits stimulatory signals to NK cells and other hematopoietic cells, leading to enhanced proliferation, cytokine secretion and target killing. They are involved in the regulation of innate and immune cytotoxic responses to tumors, pathogen-infected cells, and autoimmune diseases.
Other Names:
Retinoid acid early inducible gene-1δ, RAE-1δ, RAE-1δ
Structure:
RAE is a family of GPI-linked membrane protein consisting of alpha, beta, gamma, delta, and epsilon. They are strong homology within the family, related by 92%-95% sequence identity. They are distantly related to MHC class I proteins.
Distribution:
RAE-1 proteins are abundantly expressed in fetal tissues, but not in normal adult tissue. They are constitutively expressed on some tumors and can be induced by retinoid acid.
Ligand Receptor:
NKG2D
Antigen References:
1. Cerwenka A, et al. 2000. Immunity 12:721 2. Lodoen M, et al. 2003. J. Exp. Med. 197:1245 3. Diefenbach A, et al. 2001. Nature 413:165
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PE anti-mouse RAE-1δ
RAE-1δ transfected cells stained with Charlotte d1.23 PE
