Welcome to BioLegend’s one-of-a-kind advanced search. Search by any one of the single fields below or narrow down your searches by using multiple parameters. Looking for an anti-mouse NK cell antibody for IHC? Or looking for a FITC-conjugated antibody against a human marker for dendritic cells to use for flow cytometry? Only BioLegend’s advanced search can provide you with the best answers. If you have further questions, please contact our technical service team at 858-768-5801.
Use this document lookup tool to find Current Product Datasheets, Certificates of Analysis, or MSDS for any antibody products you have purchased from BioLegend.
Use the search box below to perform a site search of BioLegend.com powered by Google™.
PE anti-mouse/human CD351 (Fc α/µ receptor) Antibody
PE anti-mouse/human CD351 (Fc α/µ receptor) Antibody
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
Concentration:
0.2 mg/ml
Storage & Handling:
The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ≤2.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
COA:
Application Notes:
Additional reported (for relevant formats) application include: blocking binding of both IgM and IgA to the mFcα/µ receptor2.
Application References:
1. Cho Y, et al. 2006. Biochem. Biophys. Res. Commun. 345:474. 2.Shibuya A, et al. 2006. Springer Semin. Immunopathol. 28:377.
Con-A stimulated C57BL/6 splenocytes (3 days) were stained with CD3 APC and CD351 (clone TX-61) PE (top) or mouse IgG1, κ (bottom).
Fcα/µ receptor (Fcα/µR), CD351, is a type I transmembrane protein with an Ig-like domain in extracellular portion. It is a novel Fc receptor for IgM and IgA. Fcα/µ receptor mRNA has been found in thymus, spleen, liver, kidney, intestines, testes, placenta, and T cell leukemia cell lines. Fcα/µ receptor protein expression is detected on B cells, macrophages, and activated T cells. Fcα/µ receptor mediates primary B lymphocyte endocytosis of IgM-coated Staphylococcus aureus. It is involved in the primary stages of the immune response to microbes.
Other Names:
Fcα/µ receptor, Fcα/µR
Structure:
About 70 kD transmembrane glycoprotein with an Ig-like domain in extracellular portion.
Distribution:
B cells, macrophages, and activated T cells.
Function:
Mediate primary B lymphocyte endocytosis and involve in the primary stages of the immune response to microbes.
Ligand Receptor:
IgA and IgM
Antigen References:
1. Shibuya A, et al. 2000. Nat. Immunol. 1(5):441. 2. Sandor M, et al. 1992. J. Immunol.. 148(8):2363. 3. Cho Y, et al. 2010. Mol. Immunol. 47(4):878.
*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/terms). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.
This data display is provided for general comparisons between formats. Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors. If you need assistance with selecting the best format contact our expert technical support team.
Purified anti-mouse/human CD351 (Fc α/µ receptor)
Con-A stimulated C57BL/6 splenocytes (3 days) were stained with CD3 APC and CD351 (clone TX-61) PE (top) or mouse IgG1, κ (bottom).
