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The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
Concentration:
0.2 mg/ml
Storage & Handling:
The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
COA:
Application References:
1. Ng LG, et al. 2006. Eur. J. Immunol. 36:1837. 2. Ng LG, et al. 2004. J Immunol. 173:807. 3. Batten M, et al. 2000. J. Exp. Med. 192:1453. 4. Fu L, et al. 2009. Blood 113:4627.
C57BL/6 mouse splenocytes stained with 7H22-E16 PE (upper) or rat IgG1 PE isotype control (lower panel) and CD45R/B220 APC
BAFF (B cell-activating factor belonging to the TNF family) receptor (BAFF-R) is one of the three receptors that bind to BAFF. It is a type III transmembrane TNF receptor family member. BAFF-R is expressed at high levels in resting B cells and at lower levels in activated B cells, a small subset of activated/memory CD4+ T cells. It is a major mediator of BAFF dependent co-stimulatory response in peripheral B and T cells. It was reported that the mice expressing defective BAFF-R have disrupted B cell maturation. BAFF receptor appears to be particularly important for the regulation of normal B cell survival and maturation, as well as in the pathophysiology of aggressive B-cell malignancies and autoimmune diseases.
A type III transmembrane TNF receptor family member
Distribution:
Expressed on most B cells, a small subset of CD4+ T cells.
Function:
Play an importance role in B cell development, maturation, and survival.
Ligand Receptor:
BAFF (BLyS)
Antigen References:
1. Thompson JS, et al. 2001. Science 293:2108. 2. Schiemann B, et al. 2001. Science 293:2111. 3. Batten M, et al. 2000. J. Exp. Med. 192:1453. 4. Fu L, et al. 2009. Blood 113:4627.
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This data display is provided for general comparisons between formats. Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors. If you need assistance with selecting the best format contact our expert technical support team.
Purified anti-mouse CD268 (BAFF-R)
C57BL/6 mouse splenocytes stained with purified 7H22-E16 conjugated to PE (upper) or rat IgG1 PE isotype control (lower panel) and CD45R/B220 APC
PE anti-mouse CD268 (BAFF-R)
C57BL/6 mouse splenocytes stained with 7H22-E16 PE (upper) or rat IgG1 PE isotype control (lower panel) and CD45R/B220 APC
Alexa Fluor® 647 anti-mouse CD268 (BAFF-R)
C57BL/6 splenocytes double stained with 7H22-E16 Alexa Fluor® 647 (upper panel) or rat IgG1 isotype control Alexa Fluor 647® (lower panel) and B220 (RA3-6B2) PE
