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The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
Concentration:
0.2 mg/ml
Storage & Handling:
The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
COA:
Application Notes:
Clone OX-86 has been reported to act as an agonist and stimulate OX-40.
Application References:
1. Higgins LM, et al. 1999. J. Immunol. 162:486. (FC, IHC) 2. Al-Shamkhani A, et al. 1996. Eur. J. Immunol. 26:1695. (Costim)
CD134 is a type I integral membrane protein also known as OX-40, ACT35, and tumor necrosis factor receptor superfamily member 4 (TNFRSF4). This receptor is expressed on activated CD4+ and CD8+ T cells and B cells. The OX-40 receptor binds to the OX-40 ligand (CD252) to provide a costimulatory signal that is independent of CD28. Blockade of OX40-OX40 ligand interactions has been shown to ameliorate experimental EAE and inflammatory bowel disease, which implies that these interactions are important in the pathogenesis of some autoimmune diseases.
Other Names:
TNFRSF4, ACT35, OX-40
Structure:
TNF receptor superfamily, 50 kD
Distribution:
Activated CD4+ and CD8+ T cells, activated B cells
Function:
Receptor for OX-40 ligand, provides co-stimulatory signal for lymphocyte proliferation independent of CD28. Thought to play a role in the pathogenesis of some autoimmune diseases.
Ligand Receptor:
OX-40 ligand
Antigen References:
1. Al-Shamkhani A, et al. 1996. Eur. J. Immunol. 26:1695. 2. Weinberg AD, et al. 1999. J. Immunol. 162:1818. 3. Akira H, et al. 1999. J. Immunol. 162:7058. 4. Pippig SD, et al. 1999. J. Immunol. 163:6520. 5. Higgins LM, et al. 1999. J. Immunol. 162:486.
*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/terms). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.
