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The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
Storage & Handling:
The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. Test size products are transitioning from 20 µl to 5 µl per test. Please check your vial or your CoA to find the suggested use of this reagent per million cells in 100 µl staining volume or per 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. Read more at www.biolegend.com/testsize regarding the test size change.
COA:
Application References:
1. Welte S, et al. 2006. Nat. Immunol. 7:1334 2. Kuttruff S, et al. 2009. Blood 113:358
Human peripheral blood lymphocytes stained with CD56 (HCD56) APC and 5D12 PE (top) or mouse IgG1, κ PE isotype control (bottom).
NKp80, also known as killer cell lectin-like receptor subfamily F, member 1 (KLRF1), is a type II transmembrane C-type lectin-like receptor. NKp80 is expressed on the cell surface of nearly all NK cells as a homodimer with approximately 80 kD molecular mass. It is also found on a subset of effector memory CD8 T cells and γδ T cells. NKp80 induces NK-cell mediated cytotoxicity and cytokine production through interaction with its ligand, AICL (activation-induced C-type lectin), which is selectively expressed on myeloid cells.
Other Names:
KLRF1, killer cell lectin-like receptor subfamily F, member 1
Structure:
Type II transmembrane c-type lectin-like receptor, homodimer, 80 kD
Distribution:
NK cells, subset of CD8 T and γ/δ T cells
Ligand Receptor:
AICL (activation-induced C-type letcin)
Bioactivity/Activities:
induce NK cell-mediated cytolysis and cytokine release
Antigen References:
1. Kuttruff S, et al. 2009. Blood 113:358 2. Vitale M, et al. 2001. Eur. J. Immunol. 31:233
*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/terms). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.
This data display is provided for general comparisons between formats. Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors. If you need assistance with selecting the best format contact our expert technical support team.
Purified anti-human NKp80
Human peripheral blood lymphocytes stained with CD56 (HCD56) APC and 5D12 PE (top) or mouse IgG1, κ PE isotype control (bottom).
PE anti-human NKp80
Human peripheral blood lymphocytes stained with CD56 (HCD56) APC and 5D12 PE (top) or mouse IgG1, κ PE isotype control (bottom).
APC anti-human NKp80
Human peripheral blood lymphocytes stained with CD56 PE and 5D12 APC (top) or mouse IgG1,k APC isotype control (bottom)
